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00:02 e think we're cool? I'm 100 e don't even know. Do you

00:10 have a football game this weekend? cancel that one yet to even have

00:14 scheduled. I don't know. It's gonna be, like, follow me

00:18 I actually watch football regularly. what we're gonna do today is we're

00:25 cover audition and equilibrium, which I constantly refer to his balance, even

00:30 it's not balanced just easier for me do that because of bad habits.

00:34 on, Ben. What we're gonna is we're gonna look at,

00:37 some just some basic general stuff about circuitry in the nervous system. And

00:42 we talk about black basic, it's like baseline stuff and what you're looking

00:48 , this picture right here is the of how both audition and equilibrium

00:55 So if you understand the system, everything else just kind of falls into

01:00 . And so what we're looking at what is called a hair cell because

01:05 has hairs can see them. They're up, right? That's hair cell

01:10 these hair cells or mechanical receptors. is kind of cool because we've already

01:16 about chemo receptors. We talked about electromagnetic receptor, you know, light

01:23 . All right. Did anyone watch video? I posted it on five

01:27 . Yeah. Now you trust It's funny. I mean, you

01:31 watch the first five, you 30 seconds and you'll be laughing and

01:35 can stop and you'll be done with . But he actually goes through and

01:39 everything um about about and it likes . It's funny. Funny,

01:44 Alright, on DSO now what we're with dealing mechanic receptors and mechanic

01:49 It's kind of strange because you don't of hearing as being part of that

01:55 . You think in terms of sound are not turning the sound waves into

01:59 . The answer is no, you're detecting the sound waves through vibration through

02:06 . That's what you're doing. what about equilibrium? Obviously, the

02:09 of my body is going to affect Well, we'll see here. It's

02:13 affect fluid in the body, which affect how those hair cells move.

02:18 that's what we're looking at Is these cells? So these air mechanic

02:22 um, basically, they move in to movement, uh, in the

02:28 that's we're either gonna be a which we're gonna see is gonna be

02:31 equilibrium and fluid, which is primarily regards to hearing, um, the

02:39 Micrografx, which is up here at top kind of shows you what it

02:42 like a three dimensional structure. But , what you can see here is

02:47 have a, uh, keno psyllium the Siris of stereo cilia that are

02:51 attached to each other. Um, then what happens is you're gonna bend

02:55 towards or away from the Kino psyllium where you're bending and how much you're

03:00 determines the degree of opening channels. once you open the channels, you're

03:04 have potassium flowing, um, into cells, and you can see this

03:08 of backwards in little cartoon appear that area is called Indo limp. The

03:12 we'll see in a couple of slides is very similar to the makeup of

03:17 fluid. So there's more potassium So when you open it up,

03:21 Russian into the cell instead of rushes , which causes the cell to deep

03:27 . All right, so it's a a little different. Um, so

03:32 regard to equilibrium. We're gonna be at a specific structure called the Vestibular

03:36 . And so this tells us the of our head in space.

03:40 And so easy way to think about is we're gonna be working in three

03:44 or really two planes and then, , kind of in terms of,

03:48 , circular acceleration. So one of two planes got this plane, which

03:55 vertical. Wants this plane horizontal. right. And so when you're thinking

04:00 equilibrium, I want you think about things, All right? Think about

04:03 the dungeon drop. You remember? drop? No. Okay,

04:07 you're too young. Uh huh. Alaska role was long gone. All

04:13 , then you drop this simple You can go. You can see

04:15 Anything. Basically, it's one of towers. You get yourself in a

04:18 , it takes you up to the of like, tick, tick,

04:20 , tick, tick, tick, , tick, tick, tick,

04:21 , gets you top. They buzz a couple times. You think on

04:25 third, but you're gonna go. it's sometimes way after that. So

04:27 like my my second. Then they you, and you're like I'm gonna

04:30 . I'm gonna die. Gonna. then it stopped before you hit the

04:33 . And then they do it a of other times, right? That's

04:35 dungeon drop. So you're dealing with movement and then in horizontal movement,

04:40 about driving with me. All 0 to 60 in 3.2 seconds.

04:45 could do that in a pickup Yeah, teasing. Not a pickup

04:50 that be, like, four Alright, but moving in a

04:54 Have you ever done that? Where get in the car and you

04:56 You feel yourself being pressed back into car into the chair, okay?

05:01 maybe you've been in an airplane a bit more obvious. You start speeding

05:05 , and then you really confuse yourself pressed back in the seat. So

05:08 would be horizontal acceleration. So either two things that you kind of visualized

05:13 you do it. And in circular , I've already mentioned the human gyroscope

05:17 . So but anything where you're moving an angle, your head moving in

05:20 angle would be a way to think that. Alright. So that's what

05:24 gonna be dealing with equilibrium. With , we're dealing with the cochlea.

05:29 , again, I'll show you restrictions . This is going to be able

05:32 text sounds in our environment, all . And it helps us promote our

05:37 . So how does this work? if we understand this like everything else

05:42 into place will be done in 30 minutes. I don't know if

05:46 true. We'll find out. Depends I go 3.2 m per second or

05:50 ? All right, so with regard this, you can see here in

05:54 little thing, we can see that bending towards the Kilis ilium here.

05:57 can see that we're bending away from Tennessee Liam. As I mentioned,

06:00 you're doing is you have these channels are associated with the tennis ilium so

06:04 they are partially open. So if standing straight up your partially open,

06:09 allows for a rate of the polarization take place, right then if you've

06:14 towards the Tennessee Liam, you open the channel even further. So the

06:18 of the polarization happens faster. You up producing more action potentials when you

06:23 away from the Tennessee Liam, You the channel, so the rate of

06:27 polarization slows down. I don't know people can hear that my stamping their

06:33 that. So that's the general way these hair cells work. So it

06:37 matter if you're dealing with equilibrium. doesn't matter if you're dealing with

06:43 Now, I throw this up here you should be familiar with your structures

06:49 the extent of you could identify something a very general sense. I'm not

06:53 ask you to identify, for Oh, there's nothing on this

06:58 Well, like the cranial nerves or like that. But you should know

07:01 this is called. What's that called there? Called an article or a

07:10 , right? What do you think is for? What does it look

07:15 ? It's not sound absorbing. What you think it's for? Catching sounds

07:20 . Absorbing sounds would mean. It be like Grab it. I want

07:24 to look at your someone Next to is close to you. Look at

07:27 ear. That weird. Look how shaped it is. Come on,

07:32 . Here. Here. See? at that. It is the weirdest

07:35 thing ever. But this is a structure is based on how it collects

07:41 . So all those weird bumps and and turns do that. You could

07:45 there's a ear canal. There's the ear. There's a middle ear.

07:48 the inner ear. This slide is your thing. But it was.

07:52 was basically the beginning, the next . So you should be familiar with

07:56 things I talk about. When we about this structure, we're going to

08:00 straight into the inner ear. All , so this is where all that

08:06 that we're looking at takes place, and audition. All right. And

08:10 the inner ear structurally has two It is called the Boating Labyrinth and

08:14 member Enis Labyrinth. All right, bony labyrinth literally is a bone

08:18 You can see it appear. It's highlighted in green for you. This

08:23 thing, it looks like a little alien that's stuck in your head,

08:27 it's actually found in the bone. the temporal bone of the skull.

08:34 . And in here, this is you're going to see three structures.

08:38 right now, it's easy to point here to see the three structures in

08:41 here. But I'm just going to I'm going to the bottom one.

08:44 this portion right here, that's the Cleo, All right. These structures

08:49 here are collectively referred to the semi canals. And then this in the

08:54 is called the vestibule or vestibule. me. Not vestibule vestibule.

08:59 together these two structures, the semi canals in the vestibular are referred to

09:05 vestibular apparatus. All right, so is down there. It's the swirly

09:12 . What does it look like to ? A snail? Guess what cochlear

09:16 . Snail. Alright. Being snail . All right, so that's where

09:20 comes from. The best job you'll into something. That's why it's called

09:23 best job. You'll in the semi canals were not full circle their part

09:27 there. You got your names. you just love this? I

09:30 I'm telling you it once you start in your head. Wow. Child's

09:34 things for what they look like, they do. It just biology has

09:37 simple. Alright, so I've just a look at that. All

09:41 so the one thing I want to out is so the memory this labyrinth

09:45 inside of the bony labyrinth. And between those two places, we have

09:50 that Caroline is very similar to the fluid. All right. And so

09:55 is the stuff that kind of holds in the place and then inside the

09:59 , this labyrinth, what we have we have Indo lift and that in

10:03 limp is very much like I c all right. It's easier if I

10:06 write that out. I cf so inter cellular food. So it's kind

10:12 flip flopped on us in terms of this thing material has. So this

10:17 nous labyrinth is basically membranes inside the that could create these compartments that allow

10:22 thio do. Um um, you , determinar equilibrium and to help us

10:27 hear. So there are structures within other structures. One is called the

10:33 duct so that they ducked within the where the structure is that allows us

10:40 hear. All right, so we're see there's more structures there. But

10:43 thing that we're gonna be focusing on in the cochlear duct. Alright.

10:47 the vestibule. We have two We have the you trickle Mossack.

10:51 all right? So it's these two structures within this larger area that are

10:58 for, uh, that allow us determine linear acceleration. Alright. So

11:04 be horizontal and vertical. And then semi circular canals are within those larger

11:11 . Semi circular doctor, inside the semicircular canal. And it's here where

11:15 gonna be able to deal with uh, angular acceleration. All

11:21 so equilibrium. All right. The structures we're looking at are in the

11:28 tube. You'll all right? It's you trickle in the sack. You'll

11:33 , that referred to as the Odalis . The reason they're called Odalis organs

11:37 because they are a structure that is a gel like goo. All

11:44 that has a little tiny crystals jammed it. Kind of like your great

11:48 makes that jello with the with the in the grapes in it. Do

11:52 have that aunt now you don't have great aunt never married. Okay,

11:59 sorry. It's It creates a though, doesn't it? Right.

12:03 , you know, I'm talking about ever had a Jell O with the

12:05 in it. Yeah, All That was That was big stuff back

12:09 the seventies. Yeah, that's a time ago. All right?

12:16 And so you could imagine if I Jello. You guys played with Jello

12:20 , right? E u like Jell . So when I was in

12:23 you know, we would actually have was in high school. We have

12:26 O eating contest. We take Jell , You know, you get it

12:29 , you get that cut out jello the school. It's on a

12:31 You sit there and you can wiggle , you know? Just suck it

12:35 one. You ever do that E man? Okay, let me

12:40 it this way. You ever had Jell O shot? There we

12:43 Now I've got an audience. All , but if you get that jello

12:48 anything in it and you slide it the table, it will slide,

12:51 they'll kind of kind of wiggle for little bit. Right? But if

12:54 take Jello with has the fruit and inside and slide across the table,

12:58 will wiggle even mawr. Why There's greater mass in it, so

13:04 has greater inertia. So once it wiggling, it will wiggle harder.

13:09 that's what the Odalis organs do is basically have these structures, these calcium

13:14 crystals jammed into um so you can in that top picture up there what

13:19 kind of look like There's the hair , all right, the hair cells

13:23 up. So there's your hair and then you have on top of

13:27 , this gel structure, that gel is the macula, all right.

13:32 then macula has embedded in it the carbonate crystals, which we call the

13:37 , hence the painter or the term organs. Now, this is a

13:41 bit more complex side that I have here. But if you look at

13:45 picture here, you can see the arrows pointing in this direction in that

13:49 . This shows you the alignment of hair cells, and that's not so

13:52 . I'm not gonna ask you what the alignment of the hair cells?

13:54 know that the hair cells have kind this unique alignment. You know,

13:58 just kind of for your future, ? It's not that they're all pointing

14:01 the same direction. And it's how hair cells been on each side of

14:06 head that determines how your brain is your movement, right? So if

14:12 have hairstyles pointing this way, hairstyles that way and the same thing on

14:16 other side, that means when I , you know, the the hairs

14:20 one side of bending this way and other are bending or they're both bending

14:24 way. They're both bending that but it's like opposite directions. And

14:28 your brain interprets all of that stuff comes up to it with the determination

14:32 which way you're moving. So the picture here, what do you do

14:35 organs? Do they look at linear in the horizontal plane and in the

14:41 plane, two organs, you miss actual. Right, so here

14:46 are. Now, here's how we this. All right, the U

14:50 . I've highlighted all high points. have their stereo cilia sitting in the

14:54 position, right? So that means I accelerate in the horizontal plane,

15:01 hair cells bend right? So if if they're in the horizontal plane,

15:07 I'm accelerating, they don't move, they? So those hair cells pointing

15:11 and down in the vertical plane been you move in the horizontal plane?

15:15 that movement is what's detective in the ? The macula. So what happens

15:21 I begin accelerating Because of inertia? macula gets pulled backward because of

15:25 The hair cells been and that's what detecting as movement. That's the you

15:31 . So you trickle horizontal acceleration. sacral is just the opposite. The

15:35 cells are in the horizontal plane. means when I move in the vertical

15:39 up and down, that is when brain recognizes vertical acceleration. Now,

15:46 is the dungeon drop or getting an elevator. You know, when you

15:50 that elevator, you could feel it out from underneath you, or you

15:53 feel it push you up. That's sexual doing its job. I'm gonna

15:59 out here for a second, and need to be very careful.

16:03 This is how I'm gonna test I'm gonna ask you which direction of

16:07 trickle which direction of sexual. But all taken higher order mathematics and you've

16:13 learned about vectors. Right? Member . You may not remember, but

16:17 learning about them at some point, ? If you watch despicable me,

16:22 know about Vector. You don't remember ? Dude, He was a bad

16:27 . He called himself Vector because he crime with both. Come on

16:34 Gotta get watching your movies. Magnitude direction. All vectors have a magnitude

16:41 a strength and a direction. If moving in the horizontal plane, Do

16:48 have a magnitude? At what would magnitude be? Speed Right?

16:55 whichever way, appointing. All So if I'm moving in the horizontal

16:59 Aiken, measure that that that Do I have a vertical component when

17:04 moving horizontally, you see my right? Like what do you

17:11 Zero. That's right. If but it's zero, right? There's

17:16 that factor. You have to So I want you to think if

17:21 am going up a stairway or down slope. Is there a horn horizontal

17:26 ? Yes. Is there a vertical ? Yes. Okay, So when

17:33 tilting my head or moving my head and down, even though we're going

17:36 see that I'm gonna really emphasized circular . Both the Yukon sack. You'll

17:42 a component or having role in looking that sort of acceleration. So when

17:47 coming off that roller coaster and you're down that hill, there's a you

17:52 . There's a sack you'll that that being activated as well as the semi

17:56 canals, which we look at in a moment. Okay, But on

18:00 test, how, um I testing ? Horizontal Keep simple vertical. Keep

18:05 simple. Okay, Okay, So the semi circular canals deal with

18:16 angular acceleration. Now, there are canals there in basically three planes.

18:21 you remember your three planes? Got X axis, your Y axis and

18:28 Z axis so you can imagine your Semicircle canals are like that.

18:34 so what they're doing is they're looking movement in that particular plane.

18:38 how did they do this? structurally, what they have is they

18:42 this long circular canal at the base the canal. They have this wider

18:48 that has a speed bump in Alright. This wider structure is called

18:52 ambulance. That speed bump basically is like the macula. It's a gel

18:58 structure that kind of projects upward and into the fluid so that when the

19:03 moves, it's gonna move the speed . And then projecting into that little

19:08 bump is the little tiny hair Now that speed bump is called a

19:13 Ula. Now here's where we have be careful. We learned about

19:17 We now have an AMP Ula and have a couple of. So you

19:20 to know which one goes to All right, so kind of be

19:24 , right? So the ampule a container Coppola is the speed bump.

19:29 is the gel in the odor lift with all the calcium carbonate in

19:32 So just that's that's the great aunts fact. Now, when you move

19:40 head So when you say I am interested in taking another test, Dr

19:45 and you shake your head back and , what you're doing is you're moving

19:49 when I move my head this direction have two of these structures,

19:54 I have one on the left left side, one on my right

19:57 , right? And so when I my head, the fluid in both

20:00 those travel in the same direction, , because of a nurse, or

20:04 really kind of go in the opposite to kind of sit there in your

20:06 , moves in the fluid go and kind of pushes in that canal,

20:12 those cupolas and bends the couple a the same direction. But because you're

20:16 opposite sides of the head, the is detected in different ways, and

20:21 your brain is told which way your is moving. All right, so

20:27 you're in a roller coaster, I'm gonna use this as an example,

20:30 you have that loop and you go and around the loop them back

20:34 What's your head doing? It's moving a particular plane, and so you're

20:38 causing that fluid. The move and brain is saying, Oh, I

20:41 . I'm turning myself upside down because the movement of the fluid and oh

20:45 , I see that as well. kind of makes sense. So the

20:50 moves causes the couple of the been the couple of bends the hair self

20:55 and that bending of the hair cells either deep polarization towards the keno,

20:59 or hyper polarization away from the Tennessee , and it's the frequency of the

21:03 potential that tells you the speed at you're moving. So when you're sitting

21:09 still are the hair cells bending at ? You're sitting perfectly still right

21:17 Yeah, but she's shaking her No. So your head's moving.

21:21 when you're perfectly still no, you're perfectly still your specially getting action

21:28 that are firing at a very specific . But when you say no

21:31 I don't understand what's going on. all of a sudden you're actually increasing

21:36 decreasing on opposite sides. And so brain says, Oh, I'm twisting

21:40 head this direction. Oh, I'm my head. That direction, see

21:44 , is a double twist. That sense. All right, so that's

21:51 this all works. It's all the of inertia. Coppola is bidding back

21:56 forth, and so here's our This structure is the ampule.

21:59 There's your cup. Ula. I drove done it without trying.

22:05 good with equilibrium. That's equilibrium. a nutshell. Your movement is determined

22:10 the degree of movement of the stereo the penicillin and the stereo cilia,

22:15 in the direction that they're going. , sir. Use since your head

22:20 the side. Yes, because you that weight pulling it down. But

22:28 they're all firing is basically so everyone that. I want to stick your

22:31 to the side, like I don't . Yeah, like this. And

22:35 , do you get the sense that head is to the side?

22:40 right. Your brain is saying your head is tilted, your head

22:43 tilted, your head is tilted. you put your head back up,

22:46 no longer tilted. So that's actually perception is a function of the

22:53 Ilia being bent and basically the structures us that your head is bent.

23:01 the other fun one. You do as a kid. Did you ever

23:03 in the chair? And someone spins around really, really fast and they

23:05 the chair, right? What do eyes do? They're trying to catch

23:11 because your brain is because all that keeps going right? There's basically saying

23:16 . They're trying to figure out what do with itself. Uh huh.

23:21 are cruel to themselves. There's a who wanted to see how well the

23:25 are, the brain adapts, and he wore glasses that created an inverse

23:30 of the world, you know, if you we didn't really talk

23:32 But when you're light into your eyes flipped itself over backwards, writing someone's

23:37 the phobia, it's and it's an upside down in the image. So

23:41 brain has to interpret that so that we're perceiving is what's actually out

23:46 So he wanted to figure this You know, try to understand that

23:50 brain self adapt or is it just end? So he created glasses that

23:55 that image so that the image would the phobia in the proper way that

24:00 should with the way that we think should be. And it took him

24:04 three days before his brain actually But it did all right, So

24:10 you're always walking around like this Brain says, Okay, this is

24:14 life is now. And so when see things this way, that really

24:17 this is what the world looks like me. Chemical. So it's adapting

24:24 the signal, right? So it's getting all those those cells firing over

24:28 over again, but says this is normal responsiveness. So it adapts or

24:34 itself. Yes. So he perceived world Normally, Yeah, it was

24:41 longer like trying to walk like You know, I'm walking like Frankenstein

24:47 the first time when he comes off , you know, because, I

24:50 , he still saw probably probably he the world as being upside down

24:55 but it no longer became a That's probably a better way to

25:00 um you guys play video games at ? Yeah. When you sit down

25:04 , like, a first person shooter the first time, and everything is

25:07 around really, really fast, you're like this. Makes me want to

25:10 . You ever noticed that? but it takes, like about

25:13 like six minutes before your brain starts in such a way that that speed

25:17 normal. And then when you get , it's like, why doesn't the

25:19 work this fast? Right. so that's it's kind of the same

25:24 . Your brain adapted thing. this is the speed at which I

25:28 to be processing. Yeah, I don't remember. I I suspect

25:37 what it was is that one day was just like, Oh, you

25:40 , I mean, it's probably like when is when is it not

25:44 ? But it's probably more of a of a sudden, everything is always

25:49 , right? But it was kind this, this perception like,

25:52 I'm no longer tripping over every piece furniture that's in my way,

25:56 So I'm only tripping over one versus tripping over everyone who knows. All

26:03 , so let's move on to the ear because we're gonna come back to

26:06 interior because remember, in the interior have cochlear. We said the cochlea

26:10 the structure that is responsible for sound , right. But to get their

26:16 ways, have to travel through the ear. So the outer ear is

26:20 Pena and the auditory canal. It's the external auditory Metas Media means,

26:26 , tunnel in anatomy language. All , so you got the Pena,

26:30 collects the sound, the external auditory , which projects the sound to the

26:35 Panic membrane, which you collectively referred as the work locally referred to as

26:41 Your drum, and even said. name Timpani is drum. So that's

26:45 Tim panic membrane. The Tim panic is the front of the middle

26:51 Alright. And what you're gonna do you're gonna project to a structure called

26:55 Oval Window. Now you'll also see little picture. There's maybe it's

26:59 Yeah, it is showing you the window. We'll get to that in

27:01 a moment. But to get sound the inner ear, you go from

27:04 Tim panic membrane to the oval And to get there, what you

27:08 to do is you need to make membrane vibrate at the same rate as

27:13 Tim panic membrane. All right, the kim panic membrane vibrates as result

27:19 sound hitting it. And so we're deal with hurts here in just a

27:22 and what amplitude and wavelengths have to with All right. But you can

27:27 in our little cartoon up here we three bones Now there they're correct terms

27:31 the malice, the Incas in the peas. But if you wanna be

27:35 English speaking, it's hammer, anvil stirrup. All right, so the

27:40 hits the anvil, the anvil is to stir up, and the stirrup

27:43 the oval window. So when the panic membrane moves, it causes the

27:47 to move. And when the hammer , it causes the anvil to

27:50 When the animal moves, it causes stir up to move. When the

27:52 moves, it caused causes the oval to move. Now, the whole

27:56 of this structure is to create All right, so this is our

28:02 , our internal amplifier. And the we need amplification is because behind the

28:07 window is fluid and to get fluid move or sound waves to move through

28:12 , um, at the same you need to increase its amplitude.

28:18 . If you've ever tried to talk somebody in your water, did you

28:20 try to do that? Yeah. get high school, you got your

28:25 , you're looking underwater, giving each googly eyes and Ugo and she looked

28:30 little bit back to you right He never did that. Okay,

28:34 guess I love this protective self sheltered . I don't know. Try it

28:40 . It's really hard to talk under , right? So the idea here

28:44 I'm amplifying. And that's what the of these three structures are. All

28:48 now, you ever been to a ? You like concerts like live

28:53 You go in there, you're talking your friend. You get in front

28:55 the Marshall Stack. You know, Marshall Stack is right. That's the

29:01 . Plus all the speakers up on , 30 ft tall. You're

29:06 this is where it's gonna be You don't do that. Now get

29:10 of a stadium where your little tiny . Okay, you get in front

29:17 that thing, band comes out. , what do you do when that

29:22 sound comes along? What's the first you do, right? Career that's

29:27 reflex. Protect the ears. All . You also have muscles in your

29:33 that are wrapped and associated with these , the malice, secrets and stay

29:38 . And so they will reflexively contract prevent damage to the structures inside the

29:44 ear. In other words, they're prevent amplification. So now you're at

29:49 concert. First thing you do is your hands on your ears, but

29:52 a while, you take your hands . Music sounds just fine. doesn't

29:55 ? Because there's a delayed in terms the reflects. All right, so

30:00 you can hear everything even though you to yell at all your friends,

30:03 ? Don't you like the music, ? Don't you like the music?

30:09 done that? Yeah, yes, got a fun concerts. No,

30:22 . Now, ever had your ears up? All right. Have you

30:27 been on a flight years ago? not the only place. But any

30:31 you notice, what do you You pop your years right? Several

30:35 you can pop itude. Try to that stretch recon, squeeze the nose

30:41 . And if you have crying babies an airplane always take a pacifier or

30:48 they're like two year olds and they're old for the past fire or if

30:51 throw their past fire onto the That's never happened to us right before

30:55 got on the plane lollipops because sucking the same thing and manipulates the station

31:05 station tube attached to the middle ear it goes to the back of the

31:09 . This is where that drainage comes . So if you ever had to

31:12 tubes stuck into your safety and to them open because you always got ear

31:16 . That's what they were doing. really, all it does it equal

31:20 the air that's actually in that space the external environment, right? You

31:26 played with a drum? Alright, you bang on a drum, it

31:29 a nice noise. You put your behind the drum and prevent it from

31:33 . It kind of makes the thud and notice when your ears get all

31:37 up. What it happens, it's , all stuffy like put something over

31:41 . That's what we're trying to Manipulate that. So this opens up

31:45 allows you to equalize the pressure. again, what we're doing is we're

31:49 sound ways from the Pena or the through the external auditory meters to the

31:55 . Panic membrane causes the malaise. statements to vibrate causes the oval window

32:00 vibrate. And now what we're doing we're now entering into the cochlea into

32:04 inner ear. Alright, so here's cochlea. You can see this is

32:09 it looks like. It's that nice snail shell. If you look at

32:12 from the side in other words. take a slice that you can

32:15 It really does look like a snail , right? The snail kind of

32:20 around like this goes all the way and comes to a stop. But

32:23 we have in here is we remember, we have this memory is

32:26 , which is basically a membrane that through the center of it. And

32:29 goes all the way up and what does, it creates three different

32:33 One space is actually, or two those spaces are actually continuous with each

32:37 because it goes all the way turns on itself and comes all the

32:40 back down again. But we just it two spaces. And so if

32:45 take a slice search, you can see what that looks like. All

32:48 , so this is that three dimensional , and then we're just gonna take

32:52 look at one of these little but it goes all the way

32:55 all right. And what we have are the three different compartments. All

33:00 . The one on top is called scallop vestibular, or the stimulus

33:06 The one on the bottom is called Tim Panic Duck or the scallop

33:10 The one in the middle is the duct. This is one we're interested

33:14 . You know, the other ones important, but this is the one

33:17 interested in because it contains within it structure that allows us to detect

33:24 Now the oval window opens to the . Vestibular. All right, so

33:31 , we got Pena. We've got external auditory Meet us. We got

33:34 tim panic membrane. We got uh, hammer, the anvil,

33:40 syrup. So you know, the , Because stay peas, we have

33:44 oval window, and now you're in scallop, vestibular. And so if

33:47 was a straight line, it would keep going, and then it would

33:50 on itself and become the scallop So you can imagine it coming back

33:56 the way and then at the end the skeleton, pani is another

34:00 and that's the round window. So we're gonna do is we're gonna move

34:04 . That's in the scallop. Vestibular , right, Because the oval window

34:08 gonna start shaking, and that's gonna all the way back around. It's

34:11 cause around window to shake now. far, has any of this have

34:14 do with sound detection? No, just doing this is like one of

34:19 super mouse traps. You just keep stuff on, right? That's what

34:23 done. So now we have this . And so the floor of the

34:28 of the stimulus is called the vestibular . The roof of the skeleton pani

34:33 called the basilar membrane because it's all reference to that cochlear duct. So

34:37 basement or the basil membrane is the of the cochlear duct of a stimulant

34:44 has the or the vestibular membrane serves the roof. So those who are

34:49 and trying to visual this, pretend put one arm out at three

34:54 and put one at one oclock, that's the structure. You can see

34:58 in our little picture here. All , basil er, membrane, vestibular

35:04 , and that defines the cochlear Now the turning point is the helical

35:10 . Who cares what the name is ? We want to focus on this

35:14 right, because this is membrane. membrane. Now, when we go

35:18 the cochlear duct, we can now the structure that actually detects that structure

35:28 called the organ of Corti. All , now we have our vestibular

35:35 I'm gonna sit down because it's easier draw that way. Whatever the stimulus

35:43 we have here are Bassler membrane picking in the middle over here in the

35:49 . That's called a textural membrane. is a very stiff structure. It

35:53 out there like look a diving board then attached to it. Underneath it

36:00 Siris of hair cells. I'm gonna there. We're seeing on the

36:04 You can see I'm attached to there then I have one group of hair

36:11 that are not attached. All so what we have is we have

36:14 hair cells, the inner hair Is this row right there? This

36:20 , the row of the inter hair are responsible for responding to the movement

36:26 the fluid inside the cochlear duct. . The outer hair cells, on

36:33 other hand, modulate the flow of fluid inside the cochlear duct.

36:41 They have even gotten a have that moves and then the nerves responsible for

36:48 that information up all joined up together form what is called the vestibular cochlear

36:54 . That's actually the cochlear nerve. it joined up the vestibular nerve and

36:57 of creative vestibular cochlear nerve. So were the structures, and we're gonna

37:03 back. We're gonna try to put all together here, and probably three

37:07 swoops. All right, so I'm pause here for a second and

37:11 Is the an enemy grossly confusing? . Draw a picture of it.

37:16 right. If you're not drawing pictures you're going along, you're putting yourself

37:21 a disadvantage. It's like tying your hand behind your back. So draw

37:26 . Because remember what we said. have the Pena, the auditory Meet

37:32 Tim Panic membrane mallesons escapees over window , vestibular, scallop timpani, round

37:39 . Notice that the cochlear duck is in any of that pathway. The

37:43 duct sits between these two structures because we're gonna do is we're gonna bend

37:47 around each other, and it sits between them. And so we need

37:50 get movement inside the cochlear duct. though it's not part of that long

37:54 of events. The movement of the is going to take place first in

38:00 structures we just name now. What hearing hearing is simply the perception of

38:05 waves. Sound waves are like the that you're more familiar with, not

38:08 horrible, nasty waves that I showed on Tuesday. And did anyone bother

38:13 on Wikipedia to see the the gift . Did you? Is it

38:17 It was just like, What's that ? E can't do it. All

38:23 , Don't watch it. It's All right, Now So what we

38:27 here is like a wave that you're familiar with If I got a rope

38:30 I snapped it, you see that traveling? That's what a sound wave

38:33 like. Alright, the waves are what you see in the ocean,

38:36 they don't come crashing down on It's just the up in the down

38:39 . All right, so we have and intensity. Frequency is measured in

38:43 . That's basically the number of waves pass a given points. That's your

38:47 . And then this is what you think of its pitch. So if

38:50 know high notes are low, notes , then you're familiar with frequency.

38:56 , so Barry. Why versus Freddie ? You guys know very white.

39:04 . No. Can't get enough of love, babe. Come on.

39:08 is the quintessential deepest, deepest baritone rock history. Actually, not your

39:16 . More of a disco. All , Freddie, Mercury, you guys

39:22 familiar with right? Please, please your head. Yes, or I'm

39:27 have to stop this class, give all efs and make you go learn

39:32 rock history, but not your Just pretend. Lie to me.

39:38 ? Okay. All right. intensity refers to how loud something

39:48 So that's the amplitude that measured in . Right? So the louder I

39:54 , the greater the amplitude even though may not change my pitch Whisper be

40:00 But you here I said I could all the terrible things about you Wouldn't

40:15 know, right? Thats amplitude. , So high notes versus low notes

40:22 amplitude is how loud something is. , to create loud noises I have

40:27 use more energy. You notice that if I have more energy, what

40:31 you think? Sand ways. Do travel further? Right? Less

40:38 They travel shorter. That's why whispering a really interesting tool to demonstrate

40:45 You know, it's like the sound only travels a certain distance. The

40:48 . Okay, so let's put it together now in this picture, what

40:54 looking at is you're looking at the . That looks kind of like a

40:57 looking tone, right. What they've is even wound it. Alright,

41:02 the cochlear, remember, is a that kind of goes on. It's

41:05 comes back around and what they've done is they said in the cartoon I'm

41:09 unwind it so that you can see pathway so you can see in our

41:13 cartoon. Here is the scallop vestibular . It goes up, turns on

41:19 at the helicopter MMA and then comes down is now the skeleton.

41:23 So if I create a vibration that vibration is gonna work. It's

41:28 the way around to the other Except for one thing. I

41:32 it is true. That's gonna do . This is a wavelength, all

41:36 ? And so there's a distance that wavelength travels. In fact, if

41:40 watch that five g video, I you, he talks about wavelength significantly

41:45 that's one of the major concerns about g is its wavelength, right,

41:50 it's that 300 gigahertz. You hear gigahertz and you like freak out's

41:55 Oh my goodness, that sounds so because my wife I was only

41:57 five gigahertz. And the truth is he points out that when we

42:01 at electromagnetic radiation, this is the part is that visual lights is in

42:05 terror hertz range, and it's Oh, I have no idea because

42:09 always talk about nanometers right anyway, that wavelength, as you might

42:17 is something that travels up and travels down and travels up. So that

42:22 is gonna hit the roof of the vestibular, and then it's gonna hit

42:26 floor of the scallop vestibular, which call the vestibular membrane. And it's

42:30 do so at a very specific depending upon its Waverly right? So

42:34 wavelength are going to hit some place here right longer. Wavelengths might hit

42:43 way over there in a single right? And so where that way

42:49 down crashing on the vestibular membrane, going to cause the vestibular membrane to

42:56 right, Because it's a force, ? And what you can imagine inside

43:02 cochlear duct, I've got fluid. when I squeeze on something that has

43:07 , what's that Fluid is gonna have do? It's gonna have to move

43:10 . It pushes itself down. So I caused the membrane to bend,

43:14 , they're showing it here, and right, let me point out

43:17 The artist did a very crappy Why did the artist do a crappy

43:21 ? Because they drew little tiny lines over the place before it actually caused

43:25 to been. What you can imagine that that's one wavelength right there.

43:31 right, so recognize artists sucked, right, But that's OK because he

43:37 know his science. So you could it goes up. It comes down

43:42 causes the vestibular membrane to bend. when it does that that causes the

43:48 to be pushed down in that particular of the cochlear duct. And when

43:53 push on the fluid on that that's going to cause the basil er

43:57 to bend at that same point, ? And so that basically, it's

44:03 a shortcut where that energy could And so the purpose of the round

44:07 here backing up again is to allow energy to be absorbed. Do you

44:12 those little stress dolls that you could a long time ago? You can

44:17 find their like rubber, and they their like shaped kind of like a

44:20 of like like Mr Peanut and they a nine mouth and you squeeze them

44:24 . They pop out like that, , though all right, that's what's

44:28 on here is you need to have place for that energy to go

44:30 So it's being dissipated in the round . So doesn't reflect itself back again

44:35 keep recur Shang back and forth, right, So really, what we're

44:39 is we want to focus on where bend is taking place because what you're

44:44 here I am at that particular Here's the vestibular membrane again. Just

44:49 of the three o'clock in the one . Here's the timpani membrane when I

44:52 in the vestibular membrane that causes these to move at the same place right

45:02 , what did we say was in middle between the stimulus membrane and the

45:05 membrane. What was the thing that out the other membrane? Yeah,

45:09 textural membrane. Okay, I'm not talking to you, like 30 seconds

45:13 . I don't make expect you memorize . That membrane is a stiff

45:17 It doesn't move right. So what is as the baser membrane and the

45:23 membrane move, the textural membrane stays same. Okay. And what's happening

45:30 is you're pushing fluid down and around textural membrane. And because of that

45:36 membrane being reflected downward, you're actually of creating a suction into that

45:41 And when pushes upward, it pushes fluid back out again. Now what's

45:45 underneath that textural membrane? Hair right? So it bends one way

45:51 bends the other way as the fluid back and forth. Alright, so

45:55 what's going on here. All here we can see it a little

45:59 more clearly, And so each of steps there's a lot of words on

46:02 slides, and I know that I that purposefully so that when you come

46:05 and look at them, you don't to go back to the book

46:07 Look up the explanation. All but here, what you can see

46:11 kind of the structure. Here's your inner hair cell. This is our

46:15 . So remember we said the outer ourselves are attached to or embedded with

46:19 territorial membrane. And so when the membrane goes down, you stretch out

46:25 outer hair cells and the outer hair don't like that. They have a

46:29 . And I'm called Preston, which think is the funniest thing ever.

46:33 would you name a protein Preston? like naming it Jack. Right.

46:38 , how you doing? Yeah, Preston. It's a protein. I

46:42 know. Sorry if your name pressed the class. We're not making fun

46:45 you were laughing near you? Not you. Okay, so Preston is

46:50 of a protein that doesn't wanna be . And when it gets stretched

46:53 what it says No, no, . And it compresses itself and pulls

46:58 even harder on the textural membrane, really causing the basal membrane to move

47:04 a textural membrane, which creates greater in that particular area. And so

47:09 inner hair cell response to that fluid underlying the tech Torrey a membrane.

47:15 right. Okay. So what big got the baser membrane or the vestibular

47:20 moving Bassler membrane moving pictorial membrane Cause movement of fluid in that particular

47:26 . Still understand how I detect All right, well, remember we

47:32 this is a row. Let me back a couple of slides. 123

47:36 ? Right. Yeah. What we here are ah, whole bunch of

47:44 cells lined up against each other. . So you can imagine it goes

47:49 entire length of the cochlear ducts and you stimulate in the cochlear duct determines

47:58 frequency of the sound that you're detecting or what we said coming back over

48:07 , we got high frequency notes. have low frequency notes because we got

48:12 cells that go all the way along lane. So depending upon where I

48:18 in that cochlear duct, that's basically you're detecting this frequency. Guys play

48:25 , You know you're pulled piano. anyone ever seen a keyboard? 88

48:30 long, right? You ever run fingers across him, go don't get

48:35 and higher and higher or lower and and lower, depending on which direction

48:38 go. I haven't played keyboards, I don't know. I just have

48:41 of my house. It's always Have a bigger piano that no one

48:46 . All right, so you notice that's kind of what the cochlear duct

48:51 like. It's basically detecting frequencies. like I'm pressing on a key on

48:56 keyboard to create the frequent or to that particular frequency. So I guess

49:06 are looked at this one. so that's what the frequency and amplitude

49:12 is. Well, really the Alright. So, depending upon where

49:16 can see up in our little cartoon is showing you the stiffness. That's

49:21 it's showing you fatter and fatter and gets thicker and thicker. It shows

49:24 the stiffness because you want to be to respond, uh, with less

49:28 nous of these different ranges. But I'm over at the end nearest the

49:33 window, I'm picking up the high notes as I moved further and further

49:40 . I'm getting the Barry White all right. That's all it's saying

49:45 , so where I do it So you noticed? I mean, we

49:48 speak the same language. But if closed our eyes, we could detect

49:53 was talking. I mean by the of their voice. Right, because

49:58 all have a unique timber, and basically tones on top of tones.

50:05 pitch high notes, low notes, determined by where on that,

50:13 in the cochlear duct where you're causing displacement of the membrane. There a

50:18 online. If you have that them okay, good with regard to

50:22 . Amplitude is what What did I ? Well, how loud something

50:26 So if I have a high note quiet and a high note, that's

50:33 . The only difference there is the , so it's gonna hit the exact

50:36 spot. But I'm creating greater, , movement in the cochlea, where

50:43 where that's occurring, right? So can imagine when it's quiet, it's

50:47 like this. Imagine my hands shaking , very little, but when it's

50:52 , it's going up and down more . And so that's why you're getting

50:58 mawr or the sense of loudness. , so that's how we determine how

51:03 encode this stuff. All right the wave will pass all the way

51:11 that goes all the way to the window. So we're looking at the

51:16 wave. The sound wave enters via pena right through the auditory meet us

51:21 panic membrane to vibrate at a specific . That frequency is preserved through the

51:27 staples to the oval window. The window creates a wave at that particular

51:33 that hits, you know, up then down to that vestibular membrane.

51:37 now what we're doing is we're transferring energy into the cochlear duct at a

51:42 location, causing the basil er membrane vibrate at that same location, which

51:48 how we detect the sound. And energy wave then continues back towards the

51:53 window via the skeleton pani, and round window absorbs the energy. So

51:57 get reflected back in and create all of sorts of distortion sound.

52:07 Are we good with the how hearing ? You kind of sort of.

52:14 why can dogs here better than humans higher frequencies? What do you

52:22 If you had to guess, you ears or bigger. What do you

52:30 no longer okay? These air Good. Uh, but really

52:34 It has to do is just how that membrane is tuned. Right?

52:38 one of the things that way said that you know, we has that

52:42 thickness and it gets wider and stuff you can imagine there tuned towards higher

52:49 and less towards the lower frequencies. actually, women, you're tuned higher

52:53 than men are. Why, when cries at night, who gets

52:58 Does Dad get up? Yeah, could care less. You know,

53:03 not because we don't care about the , so we don't hear it

53:08 What do we hear? Bumps in night, right? We're ready to

53:13 up in, you know, Who's ever walking through our home.

53:17 it's either the trade off, less , more crying babies. But,

53:22 know, that's that's how we're There's another difference between the sex.

53:29 means it's always true. No. right, so that's that's basically audition

53:35 equilibrium. Any other questions about this from online? Uh huh.

53:47 sure. Would it be fun on you want to vomit for a little

53:52 , All right. I mean, anyone here been to the eye

53:55 and you have tow wear, You , I mean, put the drops

53:58 your eyes or they put Is it ? Do you feel No, you're

54:03 . Alright? Because your brain is . I don't understand this, but

54:07 a while, it gets used to , so yeah, you can create

54:11 all you want to. It's It's like saying, you know,

54:13 your mom used to tell you don't your eyes like that, they'll stick

54:15 that. They won't stick like Just look funny. And you're pissing

54:22 off. All right, so let's now to kind of a general

54:28 We're gonna kind of back down. walked through these systems. We now

54:31 ah better understanding of some of the senses we've looked at. How touch

54:36 . We kind of have this sense how the sensory system works. So

54:40 do we process this information? We need circuits. All right.

54:44 so what we're doing is we're gonna about stuff we already know about.

54:47 just gonna put some words to All right? So, basically,

54:51 nervous system is a Siris of We have an input. We have

54:55 processing center And then we have an e fair processing center and a

55:00 All right, so we have terms this, right? We have local

55:04 . Local circuits are basically in a region of the brain. Information comes

55:07 , it gets processed and then it's outward. Where's it sent outward?

55:11 know. Don't care. It could to another part of brain for further

55:14 . You go and cause motor movement do all sorts of different things.

55:21 are basically the same thing as a circuits that it's just more finer

55:25 So it's basically creating things and keeping in a very, very tight

55:30 So here is an example of a circuit. Alright, Not very

55:36 You can see here. I've got information coming in going into the spinal

55:40 . Basically, all the information is processed at the level of the spinal

55:44 . Information comes back out. If step on attack, right. I

55:50 through the century reception that I'm stepping attack on attacking my foot.

55:55 I lift my foot up. That all happen at the level of the

56:00 cord. So we have a parent That's the input, the fiber.

56:05 motor neuron is the output. The neurons on the center. Those are

56:09 processing unit. They could be both auditory and inhibitory, depending upon the

56:14 . All right, now, this a simple one. You can actually

56:18 other information that this isn't showing. is an example of the same

56:22 This is just up in the cortex again, you don't need to know

56:25 the different steps, but you can here's input coming in from the

56:29 You could see the output coming down different areas and then you can see

56:32 inter neurons that are located in there are responsible for processing and modulating what's

56:39 on at the level of the So it doesn't matter if you're looking

56:43 the spinal cord. Doesn't matter if looking in the brain, you're gonna

56:46 seeing this sort of arrangement. It's just gonna be unique for the

56:51 that it is. And so when go into a neuroscience class and they

56:55 talking about the six different layers of cortex and you start going Ah,

56:59 , no, no. Just back up for a second. So

57:02 apparently I'm now just looking at the know, the unique discriminations that air

57:09 this structure. Alright, because in different parts of the cortex, you

57:13 these six layers. But they have roles and responsibilities, depending upon where

57:17 are. Visual cortex has subdivisions and sub divisions of each of these

57:23 You know, the motor cortex? so much. Okay, so but

57:27 the same principle being applied over and . And so again, when you're

57:32 , look for similarities first and then out what's different and then focus on

57:36 differences. A reflex is an example one of these things. It's basically

57:45 rapid, pre programmed response in a or gland to some sort of

57:50 And so I'm showing you to physical here. But you can imagine if

57:55 smelled Oh, I don't know. think of something yummy. Uh,

58:00 know, barbecue, cooking being And if that's not your thing,

58:05 of your favorite, uh, cookie baked, you know, or

58:10 right? You get that. You , I'm talking about now. Just

58:14 about it doesn't make your mouth No, Do you not like

58:20 No. I dated a girl and You didn't like food. It was

58:23 saddest thing ever. Food was just . Now she was thin, but

58:29 didn't understand. When you go Thio , it's for enjoyment to wash over

58:34 palate to provide you joy in I'm just teaching you. But it

58:42 true. I'm just teasing. So for those of you whose mouth

58:50 notice, that's just a response. you actually see it? Did you

58:53 it? No. All you have do is think about it and your

58:57 responded to the the virtual stimuli that just provided for you. All

59:02 But you have you all done the test. You know the knee

59:08 Let's see if I can do You don't even need a hammer.

59:17 . No, just too old And I'm wearing jeans, but

59:22 if you, uh no. you guys are so lucky you're at

59:28 . You don't get to watch me on the table like a walrus out

59:32 the water. Mhm. Have to if I can do this right,

59:38 you can usually just get a Just got to hit the pin in

59:49 right spot. I'm trying to fight , too. Into it. Yourself

60:00 home is fun, fun at All right, it's always gonna

60:06 So it's a It's a pre programmed . Every time I hit it,

60:09 gonna do the exact same thing. is showing you the pupil every reflects

60:12 I talked about that last time we about The eye you can actually cover

60:15 , are split the eyes up, lighting one I it actually violates or

60:18 actually constrict. The other one stays his dilated state. All right,

60:22 those were the terms are reflexes. if you don't know what stimulus

60:26 if you don't know what involuntary can't control it, can't stop

60:29 Whatever right? Pre programmed always the in terms of the types of reflexes

60:34 have basic reflexes. You have conditioned . What you're looking at both of

60:38 cases here is a basic reflects. , people a response and the knee

60:42 reflects our basic reflects A condition reflects what you learn active after practice and

60:49 . Yes, sir. That's lost pants every time. Exactly the

60:54 That's the key thing about a Mhm. So you keep banging that

61:01 with that hammer, it's gonna do exact same thing over and over and

61:04 and over and over again. It's joyous right now. Conditioned reflexes,

61:10 little bit different. All right, an example of a condition reflects Gonna

61:16 at somebody and smile at them and they do back. They smile

61:20 right, because, you know, I smile back when I when I

61:24 at you that I'm not gonna come you Actually, the smile is actually

61:31 demonstrate. It's it's a dual It's I am dangerous. I'm baring

61:36 teeth, but I'm not gonna attack because I'm just showing you that I'm

61:42 and they just, you know, and apes. And basically that's what

61:46 do When when unf Amillia groups get , they bare their teeth. But

61:52 don't attack one another basically saying, keep it cool because we don't wanna

61:58 each other. But just let you , if you track me, I'm

62:00 take you back. That's where smile from. Alright, So practicing learned

62:06 , another condition reflects you're most familiar . That's Pavlov and his dog.

62:09 we know about Pablo and his Pavlov had a dog. What do

62:13 do? He fed the dog. like that, the doggy rang a

62:19 . So feed the dog, Feed dog, ring a bell, Feed

62:21 dog, ring a bell, feed dog ring a bell ring. The

62:23 was about dog do. He gets pissed me. Attack half block.

62:29 ? No, he's salivating. You're . That's what most dogs would

62:33 God for me if you bet me ring a bell. If you didn't

62:40 me the food, I would attack like where's my food, right?

62:44 like when the waiter shows up and your meal will be out in just

62:48 moment. Why did you come over talk to me? Should bring me

62:52 food. Okay. Have you seen picture before? Yeah, we

62:59 Right when we were describing peripheral nervous and the central nervous system, and

63:03 see it's the exact same picture. tells us the exact same thing,

63:07 we can kind of use them as global way to understand things so you

63:10 see over there. Here's the spinal arc. There's a receptor. You

63:14 see that the receptors detecting electric Thank you. See most students in

63:22 . Why don't I don't understand. a nail with lightning bolts.

63:28 Alright, so it's detecting pain. . All right. So you can

63:32 we send information up through a parent . That's part of the peripheral nervous

63:36 . It goes into the central nervous and interacts with Interneuron. Where that

63:42 processes that signal. This is what refer to as an integration center or

63:47 a processing center. These air just that we use and what's gonna be

63:51 here is the responsiveness, so notice doesn't send a signal up to the

63:55 . It stays here in the spinal , and we can see now there's

63:59 apparent neuron, a motor neuron or we refer to the parent pathway coming

64:04 out down to the muscle, And so where I got that electric

64:09 , I'm trying to move my elect arm away from the electric nail,

64:12 to avert from the pain. So the response. So the thing that

64:18 the response is what is called the er, it causes the effect.

64:23 where the term comes from. Right we have. It's a lateral pathways

64:28 contra lateral pathways, and it's lateral . On the same time, if

64:32 put my hand on a hot I'm going to use and it's lateral

64:36 to pull my hand away. All , it's not gonna be contra lateral

64:40 if that was contra lateral, I my hand on the stove and I

64:43 my other hand away, which makes one of tense Alright. But contra

64:49 pathways do become important because when I on attack while having its lateral

64:54 if I don't have a contra lateral to put my leg down, I'm

64:57 following my butt. That makes sense that the contra lateral component to a

65:03 that's occurring on the it's a lateral . All right, so the five

65:09 is basically receptor, a parent integration, different pathway effect, or

65:14 that that last step? Now I want to kind of run through a

65:17 of these. We have mono mono, synaptic versus policy, synaptic

65:21 . When you hear mono synaptic, maney synapses Do you have one?

65:26 . Don't glad this stuff to be to you. Alright, Polly.

65:30 means more than one. All And so you imagine a simple

65:35 Mono synaptic. This is showing you stretch reflex, right? So I

65:39 be the knee jerk reflex. For , Hit the knee. I don't

65:42 need an Interneuron. I'm just basically when you hit this, when I

65:46 this tendon, you cause the knee . You flex that muscle and that's

65:50 happens. All right, so it's direct communication between the sensory and motor

65:55 . One synapse there, Polly Synaptic you have more than one synapse over

66:00 the right hand side, you can a very simple Polly synaptic. This

66:03 has. How many synapses? Not complicated question. Just kind of the

66:10 of synapses. So too, Or it three? What's the synapse?

66:22 synapse connection between two cells. How do you have? Three. So

66:27 have to Thanassis. Okay. You , it's learning the terminology and applying

66:34 appropriately. It's not a trick but it feels like one, doesn't

66:39 ? All right, So what you here is you see a synapse between

66:43 A parent neuron and the Interneuron. see a synapse between the Internet and

66:47 parent neuron. So this particular place , is a to synaptic,

66:51 neuron chain. Now, this is be an example of the withdrawal

66:55 If you're done this in the you got your Bunsen burner on and

66:58 decided to burn your hand on I have ever done that.

67:01 So you can say, Oh, put my hand on the fire.

67:04 , I shouldn't be doing that. is a bad thing. I Maybe

67:06 should put my hand. No, don't even think about it. You

67:08 move your hand away. Right? there is a processing this taking

67:13 right? So the Internet on plays role in processing. So what we

67:19 here is we have this stretch reflex the gold you tend to remember.

67:22 promised we talk about it today when said, it's it's coming. So

67:27 reflects is determining the degree of stretch a muscle should be in for whatever

67:34 task happens to be. All so the easy way to think about

67:39 . All right, so if I'm my arms out like so. So

67:42 on guys that work or at I've got my arms at 90 degrees

67:46 my body, right there. And I have someone I say come

67:51 put books into my hand. One at a time. Now I'm talking

67:54 our books, not those English books , like, way 30 ounces,

67:58 know, I'm talking are good. know, £20 textbooks that really men

68:02 women carry with them to class. ? You do that at least digitally

68:10 in your brain. Okay, So I put that what is probably 8

68:14 £12 textbook that you guys have in hand what's gonna happen with my

68:18 It's gonna go down in it, ? But I don't want to

68:21 And you're standing at my head with gun at my head and says,

68:24 you move your arms, what's gonna , I'm gonna pull the trigger.

68:28 No, no, no. So do I want to do? Is

68:30 want to keep this right here, I don't want to die. So

68:33 that those books come down, I'm creating greater tension. My hands dropped

68:40 out of place. I'm gonna get . No, no, no,

68:44 . I'm gonna bring it right back to the position. In other

68:46 I need to create greater tension because muscle is over stretching from where I

68:53 to be. And that's what the what the stretch reflects does. Now

68:58 structure that does this is what is the muscle spindle. And I didn't

69:02 moving that slide over to explain this you, but you can imagine Here's

69:05 muscle. Feel like a dollar Even , during my muscle embedded inside the

69:12 . This structure that is the muscle fiber. All right, on the

69:18 of the muscle spindle fibers are skeletal . On the inside are other skeletal

69:23 , but they're separated from each One you're detecting the stretch, the

69:28 is, is trying to respond to stretch. And so what we have

69:32 the We have the inter futsal and extra futsal muscle fibers. Alright,

69:38 basically, they're neuron that protecting the of stretch attached to them and if

69:42 over stretching or under stretching, you're make adjustments to the larger structure,

69:47 that you can get that shape of muscle spindle to be the right

69:51 And that's why I try to use example here is basically saying, if

69:55 trying to hold a book right and put the book on it, it

69:58 down and I bring it back up you keep stacking books on it.

70:01 am I gonna do each time it down? But I'm bring it right

70:03 up, as can you picture So that would be an example.

70:08 this is a, uh this is truth of all these complex or these

70:13 types of, uh, reflexes. , when you're dealing with larger structures

70:21 what we're describing here, remember, each muscle that I'm contracting, there's

70:26 be a muscle that is an antagonistic , that I'm relaxing, all

70:29 And it's even more complex than that I don't have just two muscles in

70:33 arm. I got many muscles, they're all there. Um wow.

70:38 would forget the name right now. , don't worry about that. Just

70:43 antagonist IQ versus, um, theater muscle here. All right, So

70:49 is what we refer to the reciprocal so you can see that What would

70:53 a simple A system you can see the blue line. The blue line

70:58 to the purple one. So that be a modest in optic reflects in

71:02 agonist in in that same muscle. in the antagonistic muscle, I now

71:07 a policy synaptic. I have to the other muscle to relax while this

71:11 is contracting, you see, So gonna be what is referred to as

71:16 inhibition. So for every bus I'm , there's gotta be an antagonistic Muslim

71:24 moving on to the Golgi tendon, , tendon stacking those books. At

71:30 point, you're gonna give me some the books that if I keep trying

71:33 maintain me holding it up, my going to tear, Okay. Now

71:38 way muscles work, which will learn our next lecture, is that muscles

71:42 attached to tendons which are attached the muscles contract. They pull on the

71:46 , the tendon stretches, and as stretching, it pulls on the

71:51 So there's a it's not a direct , the bone interaction. There's tendon

71:56 . And so when I pull on tenant it begins to stretch. And

71:59 the Golgi tendon apparatus is embedded in tenant, and it's looking at the

72:04 of stretch in the tendon. If amount of stretching attendant becomes too much

72:10 that structure, then what it It sends a negative signal back to

72:15 muscle and says, You stop What doing basically inhibits the muscle so that

72:20 muscle relaxes and you stop the stretch prevent damage from occurring. So think

72:27 all those, like when you're lifting and stuff. He was like,

72:31 now, part of that's mental. there's a point where if you are

72:35 , put the gun to my head some point, as you keep stacking

72:39 and more weight. Eventually the Golden is gonna just tell the muscle to

72:44 , and then you're going to kill . And then I'll be very

72:47 Well, I won't have any emotion that point, but you get the

72:53 . So that's the gold attendant. one is to moving the hands,

72:58 to maintain the position. The other is relaxing the muscles antagonistic or inhibitory

73:05 flexion reflects. All right, this , um, way that um when

73:11 move something away. So, for , if I step on that tack

73:15 , I'm gonna lift up, So I'm withdrawing. But I'm also

73:19 flex the opposing legs so I don't my but interestingly enough, in self

73:24 , this also occurs when someone grabs arm and pulls you towards them.

73:29 pull away. But what do you with your other hand? You push

73:33 . That's a natural reflex. And is what is the withdrawal flexion

73:37 It's basically a crossed or crosscheck sensor the other way toe. Think about

73:42 . Alright, So withdrawal is and the cross extensive is pressing down

73:46 together it's the withdrawal reflection reflects in brain. You have regions that are

73:56 for creating patterns. These they're called central pattern generators. So they produced

74:00 rhythmic movements walking in the rhythmic Breathing is rhythmic movement. Chewing is

74:05 rhythmic movement, right? You put in your mouth, you stop

74:08 You just don't chew, Chew, , chew chew board on that side

74:11 over the other side. Choo choo . You just It's a rhythmic

74:15 And what it is basically a Siris neuron that create this generated pattern.

74:21 right, so there's pacemaker properties. synaptic interconnections between them. I'm gonna

74:26 you a picture of one not to , but just to demonstrate what this

74:30 of looks like. So this is brain stem and higher cortex, and

74:35 here, you can see, is half center model. You can see

74:38 have two different neurons entering into one's on the extensions ones acting on the

74:44 . You'd think that they both contract the same time, but it's extensions

74:48 and flexors are opposed one another. can't you don't want them to do

74:52 . So there's your network. That's localized networks showing how this would

74:57 Basically, they inhibit each other in pattern so that they oppose each other

75:03 an opposite fashion. So you end with extension and flexion extension and flexion

75:07 and flexion over and over again. what walking is extension and flexion and

75:12 leg, then the other leg, the other leg, so on so

75:15 . All right, so there's this of excitation and inhibition that basically repeats

75:23 last little bit here has to do neural mapping, and I mentioned this

75:28 , but I want to Just kind hammered home is that the brain is

75:31 , highly organized. It's not a of neuron that have been jammed in

75:34 skull case, and hopefully, things all right. In other words,

75:39 sensory system is mapped out to match structure that does the detecting. And

75:45 there are different ways to map. can see their spatial maps. There's

75:49 maps, frequency maps, chemical Visual is incredibly complex, so we

75:54 even go into that much detail to it because they have blobs and inter

75:59 and things that make no sense to except for people who study the

76:03 All right now when you hear the map and I'm gonna show you some

76:07 , I want you understand, these not like maps that we would see

76:11 we get on our phone, down detail to almost street level. This

76:16 more like the maps that people used make in the 16 hundreds of

76:20 right? It's kind of this general that kind of says OK. Over

76:23 is Africa over here's Europe and over . There be monsters. Okay,

76:29 you need to understand. Very, plastic. Very, very fuzzy Things

76:33 change depending upon how you use So here's the somatic sensory motor

76:39 So this is, uh, the region that's located around that post

76:45 gyrus of Mattis centuries in the post gyrus. The, uh, the

76:52 central gyrus is where the motor is be located. And I want you

76:56 here that map, you can see . There's the motor. There's a

77:00 . Does that kind of look like human? It looks like there's very

77:04 locations. If you're on a map out, you can see over

77:08 Here is where my feet are. here. Here is where my head

77:11 . It's just not perfect human, ? If you stood this thing

77:15 this person would be upside down, head would be upside down, and

77:18 be like, massively large, But you can see there's a map

77:23 this. So when you receive information your foot, it's going to this

77:30 of the joy Iris, That portion the cortex, when something touched,

77:36 your lips. It's going over there it always goes there. What happens

77:41 you lose? Um, Dr, we can hear you, she I

80:53 hear you. Yeah, it's on microphone microphone. So I don't know

81:01 that e can hear it, so just do that. Probably double kill

81:09 mike on this side. Um, should my microphone working it is

81:19 Okay, so I think it was one thing. All right, so

81:22 is, like, two minutes of time. Maybe three, maybe

81:25 I don't know Anyway, so you see here that there is a way

81:30 the body matches right? You can structurally how there's a map to the

81:37 for both The sensory motor area. is also true for the I and

81:43 the retina is situated. So if look at the visual cortex, the

81:47 cortex maps what you would see if took the I spread out the retina

81:52 kind of coded it. Each of axons go to a very specific

81:56 Yes, The ear is a little unique now. Yes, The temporal

82:02 has that map. It matches up cochlear duct. So you got high

82:06 low notes right in the temporal But you also have to know where

82:09 sound is coming from. And so way that your brain does this it

82:14 on how the sound echoes on is in the by the brain stem.

82:23 right, So, for example, is for the vertical plane. Remember

82:26 planes up and down, where I , You're here looks really, really

82:29 . Funny things are basically reflective so that when sound waves hit,

82:35 hit at their at a unique and then they're related to the auditory

82:40 at a different delay. So, know, if the sound is coming

82:45 or low based upon the type of , it's coming into the ear in

82:50 kind of cool right. When it from direction, it's a little bit

82:56 , right? And you can think I got two ears, so if

82:59 coming from my left is gonna have left here first before his my

83:02 Now, if I have a large length right, so basically,

83:11 the delay is what I'm looking but at high frequency, in other

83:15 , very, very short wavelength. , it's different intensities because they're coming

83:21 fast that basically you can't detect them you can with time. You know

83:26 time In between them, there's basically this'll ones louder. This one is

83:31 , you know, it's coming from right hand side. Last thing I

83:35 to mention All right, So the your brain is allowed to do this

83:41 this is I like showing because it's show this ingenious engineering of the

83:46 That's so what you have is the of the medial superior quality. All

83:52 beautiful that Okay, we start And what it is is it has

83:58 nuclei where these new neurons are And so the accident that come in

84:06 to all the different neuron. And the when the signal from the left

84:10 and from the right here come into thing, you have a delay on

84:15 far side, right? So sounds the right hand side. It arrives

84:20 at that nucleus. The one on left hand side arrived later, but

84:23 wired in such a way that when signal comes, it goes to this

84:27 and this one and this one this . And when you get the two

84:30 coming to the same neuron at the time, it gives you a sense

84:35 where that direction is. And that's that signal gets sent back up to

84:38 brain, says Ah ha is coming this side and you do it on

84:42 sides of the brain. So it's over here, it's saying it's coming

84:46 side on the other side that's coming that side. And when those two

84:49 are growing, that's when your brain the hot sounds coming from the right

84:54 out of the way of the Whatever. Yeah, you hear?

85:01 voice is already It's a lot also to do with the yelling in

85:06 All right, well, that's where going again. When we come

85:08 we're gonna deal with muscle muscle is , easy. Most. If you

85:13 this stuff was stuffed mussels easy. we come back on Tuesday, I

85:16 you also have a calibration that you to do that right? Double check

85:21 syllabus to make sure it might not this week. It might be next

85:25 . I can't remember exactly. Double Silva. See if there's a peer

85:30 calibration. E e got questions. don't know what was. It was

85:42 basically saying it was this side. I said was your brain maps to

85:47 shape of your toe, where the comes from the body. And so

85:51 you guys were saying you couldn't hear , I was basically saying, If

85:54 had something, cut your lips. a very specific location in the brain

85:59 that happens. That's all I was . And it it never changes.

86:04 has the exact thing. So this what is called the sensory homunculus.

86:09 then for the motors, Uh, . It's the same way where the

86:14 originate from is something very particular. is called the motor Homunculus and

86:20 Let's just means human like so it's it maps to something that looks like

86:25 human, that's it and Dr Way the different parts of the cerebral,

86:34 as like the mental medulla and the . I'm sorry, the brain

86:38 Do we need to know the different nerves that are associated with them?

86:41 if we do, what about if do? And again, I can't

86:46 if I've written specific question about that I teach, named, declassified,

86:51 . I think I don't really acquired . But if if I do,

86:54 very general. Like, what is ocular motor nerve do moves the

86:59 that sort of thing. I'm not ask you What is it?

87:04 You know, what are the somatic and yada, yada yada. So

87:08 don't need to know, Like the nerve 11 is for the medulla.

87:13 , I mean, but again, you if you If you want to

87:16 this simple if you if you need ever know this start obviously one through

87:20 right? So the first three, , are are basically the brain.

87:27 else is the brain stem and basically in groups of four roughly. So

87:32 four, the middle four and then first couple. So but I don't

87:37 I'm gonna do that. In I'm almost understand, sir. And

87:40 don't do that. What? I say those, I mean, if

87:43 if you have to know any of in depth, you do need to

87:47 Vegas, right? And wife, it z all of the all of

87:54 viscera. Alright, parasympathetic, this is the gray matter. In the

88:00 matter, they lie both in the cord as well. The brain Just

88:04 spinal cord. Um, uh, people question, I heard Gray matter

88:08 spinal cord and brain was like, was the specific part? Is the

88:12 matter and white matter both in the cord or just in the brain?

88:17 know, it's both. So great is specifically where you're going to see

88:21 cell bodies and neurons. And so matter is where you're going to see

88:25 acts on grave matters. Were processing place. White matter is where signals

88:30 being transmitted. All right, so two points. Okay, that makes

88:38 lot of sense. Thank you so . You're welcome. You guys have

88:40 great day. You, too. you. You bet. I'm guessing

88:46 no more questions. Uh huh. charger. Like a A.

89:00 um, you wanted to show me on your laptop. Okay. Just

89:06 set yourself up on bond. I'll take a look. So just stay

89:10 there. Don't come and take a . Let me just say what I

89:13 to save here. Um, I

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