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00:02 Alright guys, I'm gonna go ahead start. Um I wanted to show

00:06 this real quick because I got an this morning going, I tried to

00:09 the videos but I couldn't do It was an unsafe website. All

00:12 . Let me just give you a overview. The website is video points

00:17 org. It's owned by U. . Computer Science. It's actually a

00:21 that the computer science department has been for like 15 years and apparently they

00:27 have funding to update the software and you can see down here, it

00:30 enable TLS 1.0 and 1.1 it means They're outside of 1.11.1, which is

00:36 security certificate that says they're safe. . So if you're using chrome,

00:41 actually have instructions for what you to what to do right there right there

00:44 chrome, users click on advanced and to video points unsafe. It's not

00:49 . It's it's literally one of the servers and then firefox. You just

00:54 that and then it works just All right. So if you have

00:57 accessing or will have problems accessing. freak out. There's that's that's the

01:02 and it's been driving me nuts because haven't fixed it in a year and

01:06 think it's just a funding issue. , you know, if you have

01:09 grant that you'd like to give them , you should know. Okay.

01:14 let's go here for those of you are new to the class. This

01:18 the basic rundown of what we talked on on Tuesday? Go to blackboard

01:23 yourself. Do the orientation. Watch video. Um, because there's a

01:28 video that I just pointed you to a second ago. Everything I record

01:32 going to be on that video point by the book. Start reading

01:35 We have homework assignments. We have before class, homework assignments after

01:39 The first two assignments have been extended you know, you're adding the class

01:45 I'm not gonna click individuals so everybody the extension. So yeah, drop

01:51 . Okay. We're good. You yet? It was cold this

01:57 It was gray. It is like toughest week ever. Remember all those

02:02 you made last year to yourself. you remember you said next semester?

02:06 gonna, or maybe you said this is going to be different.

02:10 you didn't do that. You're going change some habits. Okay. This

02:15 it. We're ready to start rocking rolling. Today we do A and

02:19 . And the first thing we're going learn about is the organization.

02:24 Oh, now I know what I'm . I'm like, oh, I'm

02:27 I plug something in wrong. All . So what you're looking at up

02:31 is what we call an organizational So the first thing you need to

02:35 about biologists and scientists in general is like to put things in boxes.

02:39 makes things easier for us to understand . It helps us to see

02:45 Um I knew this was too There we go. I hate hearing

02:49 own echo. Can you still hear okay? Yeah. People in front

02:52 can hear me just fine, middle . Okay, good. All

02:56 So what this is showing you is we look at a body.

03:00 We like to to take things and them down to the smallest component and

03:05 ask the question what's going on there then work our way back up to

03:10 how the organism that we're looking at functions. Alright. And so you

03:15 see here we have multiple levels. , if I was designing this,

03:18 would have flipped everything around. But drew this picture out didn't really understand

03:22 . So I would put down here up there. I'd put down organism

03:26 kind of say the baseline. The block of everything are chemicals. All

03:30 now, we're not a chemistry We're gonna talk about some chemicals because

03:34 need to understand that you are made of chemicals and that these chemical reactions

03:39 the chemicals that build or are used build things that become functional. So

03:46 we're gonna be starting there just briefly kind of say, yeah, here's

03:51 baseline. But then what we're going we're going to jump into And look

03:54 what are called the cellular level. your body is basically a bunch of

04:00 made from chemicals. The cells are basic building blocks of everything. There

04:05 about 240 different types of cells plus -20 that we've identified. And

04:12 scientists like to name things, Have guys noticed that we have names for

04:15 virus? You know that everyone's all out about right now? What's,

04:18 the current version? Oh, Yeah, those are just the big

04:24 named one. There's actually about 50 60 different variants that they've already

04:28 But they get really boring names like a which is basically a description of

04:35 chemical makeup of the mutation in a one. So after omicron, there's

04:39 be a pie and after pie there be a row. And right now

04:42 are scientists around the world racing to in the next variant because they get

04:46 put their name on a paper and big grant money for doing that.

04:50 they get to freak you out a bit more. Alright. And believe

04:53 or not, there were lambdas and . I mean you knew about

04:57 but there's epsilon and all the other in there. So if you know

05:00 greek alphabet, we're basically up to , in the greek alphabet.

05:04 Anyway, so lots and lots and of different cells and probably over time

05:10 going to be even more of But cells are used to build tissues

05:14 each of these individual cells in your have unique properties and unique features that

05:20 them to do some unique things. a compartmentalization of functionality in the

05:26 And what cells are used are used make tissues. Alright. So tissues

05:30 simply cells of the same type, together to provide a larger function.

05:37 there are four basic types of We're going to look at them basically

05:40 . And then as we move into semester we will then dissect out and

05:45 more deeply at each of these individual . But we have epithelial, muscle

05:49 and nervous tissues. That's really There's four of them. All

05:53 And then so what you do is take different combinations of these tissues of

05:57 or more. So you can have different tissues. And if you take

06:01 of those tissues together, you can an organ. Now most of your

06:04 have all four types. But there some that don't. And so an

06:08 is when you take these tissues and perform some sort of specialized function to

06:13 some sort of structure that creates a function. So for example, your

06:19 has a job, what is this of the stomach in real basic terms

06:24 . Alright. Your eye is an . What does it do vision?

06:29 you see each of these structures, and I have four of these

06:35 right? They have all four different . But the cells that make up

06:38 tissues are unique. And so that unique functionality in these two different

06:43 Eyes allow you to see or detect that some it allows you to digest

06:50 . So that's what an organ It's a specialized structure that has unique

06:54 . And then you get a whole of these unique organs together and you

06:58 them together in a mishmash. Not . But it's highly organized. Hence

07:02 name organ. Right? And what end up with is an organism and

07:07 what you want. You're an Alright. So basically the sum total

07:11 all these different things together creates So when we're looking at you and

07:17 the purpose of this class is, just go wait a second. You're

07:20 just a you you are a bunch organs that have unique functions. Let's

07:25 out what those functions are. Let's out what those organs are.

07:29 now we have these organs. What they do? How do they do

07:32 ? Well, we have to know tissues are there. And if we

07:35 what tissues are there? Well, see what kind of unique cells are

07:39 there to make that happen. And then we asked the question is

07:42 do cells change become unique? that's when you need to know what

07:46 of biomolecules, what sort of chemicals up that cell. All right,

07:52 the good news is a freshman level . I mean it's 2000 level courses

07:56 a freshman level class. We're not to go diving really that deep.

08:00 gonna be wading into the pool in lot of different places. All

08:04 So we're not going to sit there go, okay, let's look at

08:07 unique pathways of every single molecule in cell and see how it works.

08:10 not what we do here. All now, in order to understand a

08:15 thing, a living thing has to five different characteristics. Or they have

08:20 five different characteristics. Alright, so off, they produce energy and they

08:24 energy. Alright, So there's energy and there's a way to put that

08:29 in the body consumes. So, can think of it as how do

08:31 consume to produce energy? You eat ? Right. So that's easy.

08:36 plants are living things. They don't food with the small exception of a

08:41 of different plants. So how do consume? What do they do they

08:45 sunlight? Right. And what they is they use that sunlight to produce

08:49 . Alright, so this process of energy and consuming is called metabolism.

08:56 . You probably use that word at point where it's like I have a

08:59 metabolism, I need to eat something really you're not using it absolutely

09:04 but they are using it partly You're basically saying my metabolism is how

09:09 produce my energy. So I can stuff. So what metabolism is is

09:13 sum of all the chemical reactions that your life functions. Alright. And

09:19 can be broken down into two Alright. Things I make or things

09:22 break are the things I make are the process of anabel is um

09:29 anabel is um simply is is I'm take large molecules or really small

09:34 I'm gonna build large molecules from metabolism on the other hand, is

09:38 opposite that you can think about as . Right? What do I do

09:42 I take a cheeseburger and I break down in a little tiny cheeseburger

09:47 And then I take those cheeseburger molecules do things with them. That would

09:51 a tabal ism that taking the cheeseburger . But you didn't know there were

09:56 . Right. And you turned them small itsy or the big things and

10:00 turn them into the small things. right, now, that word anabel

10:04 um you've used or heard before. ? When weightlifters, weightlifters use illegal

10:10 . What type of drugs are they anabolic steroids, right? They're using

10:15 to build their muscles. So, is just where that word comes

10:18 It's talking about building also growth and . This is basically increasing in size

10:24 specialization specialization. Now this increasing in . Should be kind of an easy

10:30 to think about when you're born. . You'll remember that. No.

10:34 big were you when you were All right. You're like this some

10:39 you might have been like this. most of you are like this.

10:42 right. And now look how big are. Right? You're six ft

10:46 . Some of your forefoot something. you're bigger than this. That's an

10:49 growth thing to envision. Right? you have tissues that are also growing

10:56 the time. And what happens is started out life simply as two half

11:03 . Right? You had mom's over . You had dad's sperm. I

11:07 this is not fun to think about parents having sex, but they

11:11 And you brought that over in that together. And they created a functional

11:15 cell. Alright, sperm and all them are not functional whole cells there

11:20 cells. Right. And you bring two things together. And you started

11:25 life as one cell, One cell 22 became 44 became eight. After

11:31 . You don't get even division somewhere 12 and 16, depending.

11:35 But what you're doing now is you see this is growth. And then

11:38 happens when you start getting to that stage or 12 cell stage or 16

11:43 stage is you start seeing cells becoming . They start differentiating from each other

11:48 specialized, Right? And this is you have these unique tissues and organs

11:54 your body is because cells through this of division and growth start moving away

12:00 pleura potency basically is being able to anything and becoming specialized all right over

12:07 course of your life you are becoming and more specialized. Think about you're

12:11 a general education, then you get college and you start getting a specialized

12:17 , moving down a specific degree you go into graduate programs perhaps or

12:22 program and you're becoming even more specialized if you can think about medicine you

12:26 become more and more and more I have a friend who works at

12:29 . D. Anderson 18 years of post high school. Can you imagine

12:38 ? 36 years was when she was with her education? Right. I

12:42 she started off if you think 18 to get through high school and then

12:45 18 years that's specialty. Right? works on one type of cancer.

12:53 it. I don't know a lot anything else but that thing she knows

12:57 lot about. I'm just teasing she a lot. Alright anyways this repair

13:02 is something that happens as well. part of the growth thing. This

13:05 how we fix breaking cells are broken . And speaking of cancer, what

13:10 is when cells malfunction the body fixes or destroys them right? And so

13:16 can imagine through your entire life you cells that are malfunctioning all the

13:20 It's just that your body checks and that stuff very very quickly during life

13:24 you're like okay, it's gone? you can think about it. I

13:28 my body is fighting cancer all the because cells are always malfunctioning. All

13:34 , adaptation. This is two different how we respond and maintaining a balance

13:40 homeostasis in our body. So responsiveness the ability to sense and react to

13:45 . You all woke up this How did it feel cold? What

13:49 you guys do besides crawl back under sheets and put a jacket on?

13:53 like you're like checking to see how layers can I put on to stay

13:57 . That's adaptation. Alright now really us humans don't adapt the same

14:04 So you can think about like you a dog or a cat right now

14:07 dog during during this time of year increased the amount of for that they're

14:13 to ensure that their warmer during the months. And then in the springtime

14:18 when they start shedding like crazy when like pet them and you get this

14:21 old handful hair. You notice that ? Because now they're adapting and getting

14:26 for the warm weather. All right the other thing is is you probably

14:31 when you're cold this morning you started something, What did you do?

14:35 shivered right Alright. This is basically body's ability to maintain a constant internal

14:42 despite the fact that the outside temperature changed Yesterday? It was 70°. Were

14:48 guys sweating? Did you find that were sweating a little bit?

14:54 I was I thought it was gonna cold. So, I put on

14:56 layers. I was wearing a sweatshirt this. And you know, and

14:59 like, why is it so It was supposed to be cold.

15:02 look it's 77°. Well, why am wearing all this stuff? Right?

15:07 my sweating and the shivering that we this morning is a function of I

15:12 to maintain a constant temperature in my . Those hunger pains you get when

15:18 hungry is because your body is lacking and so your body is telling you

15:23 up and put nutrients in my body I can do the things I'm supposed

15:26 do. I'm maintaining a constant availability blood sugar when I'm trying to eat

15:34 . That would be the example. lastly is reproduction, reproduction can fall

15:38 two categories at the cellular level. talking about cell growth and repair,

15:42 kind of falls back up into this . So, you can think about

15:45 skin is constantly replicating itself and and replacing dead skin cells as they slough

15:52 . That would be an example of . But even when you hurt

15:55 if you ever cut yourself, you'll that you get a scab and that

15:58 protected and grow these cells grow back place and where the damage had

16:03 Alright. So, that would be example of a type of reproduction.

16:08 . But also reproduction is what we about when we think about creating new

16:12 . I mean typically when we think , that's what we think about.

16:15 reproduction can occur at different levels. reproducing an organism or replicating and reproducing

16:22 cells to replace dead or dying Okay. Now, if you don't

16:28 these five things were really four Excuse me. Better learn to

16:34 You're not living. I want us know something interesting. I'm going to

16:38 the virus again. Virus we study biology, Right? That's where it

16:43 in. But it's not a living , right? It can't produce its

16:48 energy and consumption. It's dependent upon cell that it infects to do those

16:55 . It does not undergo growth or . It. Just replicates. The

16:59 thing it's good at is this Right here creating new organisms.

17:04 It doesn't really adapt. I don't . We could make the argument that

17:08 it does all right. But the is if you don't have if you're

17:13 one of these things, you're not living organism. Alright. So,

17:17 you're thinking of yourself for anything that's , it has to have these four

17:23 . So, I told you today going to skip over the biomolecules.

17:26 know that there are chemicals that make cells. And by the way,

17:29 I talk I know I talk fast I just kind of go if you

17:32 a question, you can stop Alright. In fact, that's probably

17:36 good way to get me to shut . No, she's like I'm writing

17:41 down to get him to shut You can ask the question. You

17:45 have to make yourself obvious because all see are hats and heads. And

17:50 if you're just doing this, I'm really going to see. All

17:53 So, what we're gonna do is gonna start at that second level,

17:56 very briefly to kind of look at in a kind of a broader

17:59 So, cells are the living unit life. It's basically the building block

18:03 tissues in multicellular organisms. But even smallest organism that exists is at the

18:10 level. That's the basic structure. , what we have over here is

18:14 pro carry out this is a you out we are a type of eukaryotic

18:19 just a multicellular eukaryotes. So, carry out you can think of as

18:23 bacteria. Right? And so what have they have all the machinery to

18:28 homeostasis within that cell, right? they're able to function and respond to

18:33 environment and maintain a constancy within them sales regardless if your basic like a

18:39 carry it or more complex like au are going to have These three things

18:43 gonna have a membrane, right? basically serves as a boundary between the

18:48 environment and the internal environment. And you've done here is you've created a

18:54 environment for chemical reactions, right? isolated an area and that's what makes

19:01 sells unique. It's like I'm going create an environment so I can do

19:05 that I can't do outside of this . It has genetic material that allows

19:10 to replicate itself. You can see in the pericardial. It's a nuclear

19:15 . Alright. It's not highly It's more organized than we think it

19:19 , But it's you look at it Yeah, it just looks like spaghetti

19:22 everywhere. You know, in a area. We have a different structure

19:26 which that nuclear material has been Alright. And then there's some sort

19:31 psychedelic fluid. The fluid is the in which the chemical reactions are taking

19:37 . All right. So, it matter which type of organism you're looking

19:40 simple or more complex now as human cells have really any higher order

19:48 what we would say is more complex have membrane bound organelles that lead to

19:53 compartmentalization and they have unique gene It leads to specialization of the

19:59 Alright, I wanted to address this one, and I want you to

20:02 about where you live, whether it your apartment, a single space,

20:07 room or in a very large Do you have unique compartments in those

20:14 you do, Right. And think , I'm gonna use an apartment is

20:17 easy one for me. Do you a special place where you cook your

20:21 ? Yes. What do you call kitchen? It's not the bathroom.

20:26 . What's the bathroom used for showering other stuff. Right. Is there

20:33 place that you sleep in? It's the bedroom. Sometimes it's the

20:39 . Right. When you're watching I guess you guys don't watch Tv

20:43 . You're all youtube stuff. You're . But you have a kind of

20:48 an area where you can entertain, ? These rooms have unique functionality.

20:55 unique spaces where unique things happen. the organelles do is they create unique

21:01 within the context of the cell. , specific types of chemical reactions can

21:06 place. All right. So, not going to cook in the

21:10 You're not going to entertain in the in theory. Right? You're not

21:16 to sleep in the kitchen because there's an environment there for that to be

21:21 successful endeavor. I mean, you could do these things, but

21:25 really have to stretch your mind to that happen. Right? So,

21:30 we look at these organelles, I you to think in terms of,

21:34 , something unique must be happening If I have differentiated the space,

21:40 unique is occurring in terms of gene . This is working back down to

21:46 chemical level. Every one of your has the exact same copy of

21:52 I'm going to say that knowing full that I'm lying to you because there's

21:56 caveats in there that we don't need get into. All right. So

22:01 can just say every one of my in my body is exactly the same

22:03 just nod your head and go that's absolutely correct doctor. Right.

22:07 what makes each cell unique in terms its properties is which genes are being

22:13 on and turned off within the context that D. N. A.

22:19 makes sense. In other words, can think of it like this.

22:22 the instructions. I need to do in my body is in each cell

22:26 I'm not reading every instruction. I'm reading the instructions for this particular cell

22:31 do this particular function. You have genes. You don't want to turn

22:37 all on. You only need a of genes turned on in each

22:40 All right. And that's what specialization . Now. I said you started

22:47 life as a single cell alright, as you start differentiating, Alright,

22:53 you start off as Tony potent or is another word, Tony potent means

22:58 all Pluripotent means mostly. All This plurality versus totality. And so

23:05 happening is as you start moving away that Tony potent state. You become

23:10 and more and more specialized until you unique. So you can think of

23:16 Tony potent cell as being like a cell. It can do anything just

23:21 you were when you were three years , your potential was infinite,

23:28 It was, you could just you be president of the United States,

23:31 could lead a corporation, you could a physician, you could be a

23:35 . All those things are all possibilities your future. But as you move

23:39 specific tracks, certain things start getting out. Right? You know,

23:45 you move towards, oh, I know. Let's say you've grown interest

23:48 business. The probability of you becoming physician is becomes less and less and

23:55 , right as your interests are driven a particular direction. Now the good

23:59 for humans is we can always go and do new things for cells.

24:04 can't, once you differentiate down specific , you're down that track and you're

24:10 . Once you become a muscle you can't change your mind and become

24:13 neural cell, right? There's nothing can do you can do to make

24:18 go wait a second, I'm gonna backwards and become what I want

24:20 you know, become something else. you're moving in a specific direction and

24:25 you move into a specific direction, stuck there and you now have a

24:31 function. So muscle cells are different say liver cells. All right,

24:37 parasites, you're different than absorbed of in the intestine. But you all

24:43 at the same place. There's a example a couple of years. Some

24:50 you are going to go back to high school for a high school

24:53 It's probably not the high school You'll probably go to some hotel and

24:56 and you're gonna run into all your school friends. I'm not talking like

24:59 five year reunion. I'm talking like 10 and the 15. And you're

25:02 see your friends that you grew up you don't see anymore. And you're

25:06 what they do and it's gonna be , wow, you went down this

25:09 , you went down that track. had no expectation and because you guys

25:12 all the same. Oh, I you have no idea. There's some

25:15 weird stuff. Yeah. Um of my college roommates, um two of

25:21 went in academics. The probability of happening is like nil, you

25:26 I don't know why I wasn't interested academics when I was in college.

25:29 the other one he was. And fact that he went was not

25:33 The fact that I did was so we when we met up again,

25:36 like, you're a professor at, eventually said, yeah. And I

25:39 at him and said you're a professor auburn. That's really scary.

25:44 Anyway, so here are the Alright. So we've got cells cells

25:48 specialized because they differentiate. Alright, are simply groups of cells a similar

25:54 and function and they perform some sort related function. We said there's four

25:59 epithelium connective muscle and nervous. And the basic things that they do epithelium

26:05 as a covering tissue. Your skin an epithelium connective tissue connects things even

26:11 in its name, its support tissue . You're familiar with this movement,

26:16 tissue you can think of in terms controlling things. All right now,

26:22 organs have all four tissue types, not all of them have all four

26:26 . So really the definition of organ two or more. But generally

26:30 you're gonna have four. All four them present when you're looking at an

26:35 . Alright, so here's some some more detail about them. Alright,

26:40 we said that epithelium epithelium tissue or is the term we use basically is

26:46 sheet of cells that covers the body . That's the easy one. But

26:50 sometimes forget. It also lines the of the body, which we're going

26:54 look at at the end of class . All right. So typically what

26:58 do is they provide a surface through things may be secreted or things may

27:02 absorbed. Alright, so basically it's barrier between the inside of the body

27:08 the outside of the body. Now going to make a statement here so

27:12 you can clearly see this. You like a donut. Alright. You

27:17 think of your digestive system as a , through your body Like a donut

27:21 a hole. Alright? So if stick your finger through the hole,

27:25 not in the donut, are It's just in the hole of the

27:28 . All right. The meat of donut, which is not meat.

27:32 the dough of the donut, Is the inside. All right.

27:36 if you stick your finger into the , you're now inside the donut.

27:40 right. The same thing is true you. If you stick your finger

27:43 your fist or whatever into the digestive , you're not in your body,

27:48 still outside the body. All You're just in the hole that travels

27:52 your body. Okay? The inside your body is not in contact with

27:58 external aspects around you. Alright. not exposed to the external environment.

28:05 that make sense? Okay. So we're saying here is that this epithelium

28:11 that barrier between those two parts of body, right? The materials that

28:18 up your mass versus what's around All right. All epithelium has two

28:26 to it has an atypical surface. what we refer to as basil lateral

28:31 because here's the basil side and then lateral sides are basically how they're connected

28:35 each other. And why we point out now now is because the typical

28:41 is unique in that it can absorb secrete the basal lateral side. On

28:46 other hand is structurally very, very . It doesn't play a role in

28:51 or secretion, it serves more like barrier. All right. And

28:56 we'll look at this in more detail we start talking solely about epithelium a

29:00 bit later. But that's one of unique features is that you can look

29:04 the epithelium and say that is the side. That is the basil

29:09 The basil side is attached to usually tissue. What we refer to as

29:14 extra cellular matrix. Yes, It's always facing the open side.

29:23 ? So, it's always expect if typical side. The question was,

29:27 is the typical side? Basically the side is always facing the open

29:32 The basil side is always attached to . Right? So, if you're

29:37 at your epidermis, you're looking at skin. Um What you're looking at

29:42 this would be the typical side. side you can't see that's actually internal

29:47 . That would be the basil All right. And the good news

29:50 we're going to go over this again then we'll go over it one more

29:54 . So, yeah. Alright, is the interest of. Alright,

29:59 , you guys are familiar with this of muscle, which is skeletal

30:01 but they have different types, but muscle zz muscles that contract. I'll

30:06 . All right. And basically the are a result of what's inside that

30:10 . The side of skeletal elements which we talk about sales will go into

30:14 details about that. Alright. this produces movement. Now, when

30:18 think of movement, you think of movement, right? The idea of

30:22 being, you know, local being able to move parts of my

30:25 . But movement also means moving things hollow organs. So, pumping blood

30:31 example, and moving blood or moving to your digestive system. Muscle does

30:36 as well. And there are different of muscle, skeletal for locomotion,

30:41 muscle right here is muscle that serves a pump to move blood through the

30:46 . And then we have smooth muscle is found within the hollow organs.

30:50 , we'll go into lots of detail this when we talk about muscles.

30:53 , So, this is just kind the intro of that nervous tissue is

30:58 found in the nervous system, but found all over as well. It's

31:03 is innovating providing the nerves and the from the nervous system to those other

31:10 . There's two major cell types that going to be found in the nervous

31:15 . Alright. And what we tend do in these types of classes.

31:18 focus on the first one, which the neuron. Alright, So the

31:21 is responsible for producing and uh I'm gonna do it this way.

31:26 receive process and transmit. All So, it takes information in processes

31:32 and sends information out. That's primarily its job is. All right.

31:37 so when we think about the nervous , we're thinking about signals and that's

31:41 what neurons are responsible for. All . But the majority of the nervous

31:47 is made up of these different types cells called glial cells. Glial sounds

31:51 glue, doesn't it? Well, what it means. All right.

31:54 the cells that hold everything else together these are actually rather important. They

32:00 a role in supporting nourishing and protecting neurons. Alright. So, the

32:05 play a role in signaling the glial . Make sure the neurons can do

32:09 they're doing. All right. They play a role in transmitting information.

32:14 . And again, half of our of A and P. One is

32:19 talking about the nervous system. It's an important system. So, we'll

32:23 spending a lot of time around these . But today, that's all we

32:27 to know. Finally, we got tissue. And connective tissue can be

32:32 confusing because there's lots of different types some of you look at, you

32:36 , that really connective tissue that they that doesn't make sense to me,

32:40 . The reason connective tissues, the the varying types are is because they

32:44 the same origin. Alright. We're gonna talk about um uh embryonic origins

32:51 these tissues or embryonic tissues in But there's something that's called the Mezzanine

32:55 very early on development, A group cells differentiate and become the mezzanine kind

33:00 from the mezzanine kind you get the tissues. So when we're sitting there

33:04 this is a connective tissue and that's connective tissue. You're going I don't

33:07 how they're related to each other. because of that original origin.

33:12 But generally speaking, what connective tissue that provides support to other tissues and

33:17 ? Alright. So typically when we of a connective tissue we think of

33:21 that looks a little bit like this right over here. Okay. And

33:25 not gonna go into the picture but can kind of see it. It's

33:28 oh there's fibers and cells and other in there. Great. But that's

33:33 the only types of connective tissues. for example is a connective tissue.

33:37 . All it has is it's basically liquid environment and it has cells in

33:41 liquid environment. Alright. So there's whole different type, a whole bunch

33:45 different types of connective tissue. All . Um They're going to differ in

33:50 cell types. They're gonna differ in fibers that are there and they're going

33:53 be different in their matrices. The is is the environment in which you

33:57 the cells and it's that matrix that its function. Yes sir. Oh

34:03 a big ugly word. Mesenchymal mes . N. So mesen and then

34:08 C. H. Y. E. I'm never gonna ask you

34:11 on the test but if you want put that in. That's fine.

34:13 related to each other. Medicine. did I get it? Get

34:17 Okay. Alright, so again, going to spend the day talking about

34:22 tissue. So this is the gist now. Right, connective tissues connect

34:28 play a role in support. what we have up here is a

34:30 of an organ. Well, sort there's the organ up there. It's

34:34 stomach. And what I throw this here for is not for anything for

34:38 to memorize. It's to look at say, okay, can I see

34:41 tissues that make up this larger So, what they've done is they

34:45 this region of the stomach and they're out a little tiny sample to

34:49 let's take a look and see what can see. And so out here

34:52 the surface that's epithelium. You can it right there, close up even

34:57 . Alright then all the yellow stuff in this picture that's connective tissue.

35:02 . And then you can see here down here and down there and down

35:08 . Those are layers of muscle, layers of muscle. And what this

35:14 picture isn't showing you is the nervous responsible for innovating the muscle because you

35:23 have something to tell the muscles what do. All right. But the

35:26 didn't draw that in there. here's just an example. You can

35:29 it's not just like, okay, got one and then I got one

35:32 then I got one and then I one. There's three layers or actually

35:36 more than it's really the muscle muscular um mucosa. Then we have the

35:41 which has three layers in it. there's multiple layers of muscle. And

35:46 reason you have multiple layers of muscle the stomach is because you need to

35:49 different types of things with the You need to squeeze it. You

35:53 to compress it and you need to it and so you have different layers

35:57 do different things. All right. each of these muscles are there for

36:02 specific purpose? The different types of tissue. You see up there are

36:06 for different purposes. Right? The has different types of cells in

36:11 So it has different roles. Some those cells secrete some of those cells

36:16 . So there's different roles. And the idea here is that you have

36:20 these different tissues working together to accomplish function and what was the function of

36:25 stomach Digestion. Alright, excellent. in MP two you get to learn

36:30 little bit more about how the stomach and what it's doing. We don't

36:33 it in this class. All So we've run through cells. We've

36:39 at tissues in very brief ways. we're going to start talking about organ

36:44 . All right. And we actually last one really was about an

36:47 Alright. So this slide shows you stuff we're going to cover in a

36:53 one. Alright. We're gonna look the Integra Mint, which is the

36:57 binary system. We're gonna look at nervous system and we're gonna look muscular

37:01 now depending on which level you're at in our level a Mp one.

37:07 throw the muscle in the skeletal system . So muscular skeletal. When I

37:11 another class called comparative anatomy, we those two systems and we separate them

37:15 . And we spend a lot of talking about the skeletal system and very

37:19 time talking about the muscle system. there's rationale for those things, but

37:23 speaking, because the muscular skeletal plays role in movement. Support and

37:27 muscles do that, skeletons do That's why we're jamming them together.

37:31 what do we have integer Mint plays role in protection. It includes your

37:36 , your hair, your nails, sweat glands, and oil glands.

37:39 , so it's a whole bunch of types of things, glands and layers

37:43 cells that protect the outside or protect inside from the outside. All

37:48 The nervous system you can hear. got brain. They're trying to show

37:52 all the little nerves and not all them are here in blue.

37:55 basically the nervous system are these structures brain and spinal cord plus the nerves

38:00 are affiliated with this system that go and from all the organs in the

38:06 again, their job is to coordinate between the different organs and telling them

38:14 to do. So, for have you ever touched a hot

38:18 Yeah. Didn't it suck? What you do when you touch a hot

38:21 ? Did you just think about it go this is unpleasant? No,

38:25 put your hand on a hot stove you pulled it away? Alright.

38:28 was all directed by the spinal It's what we call a um Now

38:35 can't even think of the word and so simple reflex. There we

38:38 That's see this is bad, The reflex is a reflex response.

38:42 a stimulus comes in, you it tells you what to do.

38:46 respond? So that's what nervous system . It plays a role in looking

38:51 the signals and then coordinating the response them, as we mentioned, musculoskeletal

38:57 . So you can see here's there's a skeleton in between and then

39:00 them together basically movement. That's the part. Support and protection.

39:06 I'm gonna hit right here. It's to sound a lot of fun because

39:08 microphone, you hear that? It's , isn't it? What's that

39:14 Checking my heart, isn't it? heart sits in the middle of my

39:18 . Pretty bad. If I sit and can poke my heart. That

39:21 not be a good thing. All , So that protects what's up

39:26 My brain, all my knowledge. right up here. Imagine if I

39:30 have that squish, squish squish. good. And actually, if you

39:35 know um in the anatomy labs, get to work. You know,

39:39 get to dissect things and have You come across the brain. Everything

39:42 there is fixed, meaning it's been with chemicals so it doesn't fall

39:47 And so, you kind of look these things and they're like hard

39:49 right? The brain is like warm push into it. It's really

39:57 And then it also plays a role producing your red blood cells and white

40:01 cells for that matter. Okay, , in A&P. two, you'll

40:05 to cover these systems as well. right. We're not ignoring them in

40:10 system. It's just how the How am p. one and two

40:13 broken down across the country. we have the respiratory system.

40:17 respiratory system basically includes naval passage tricky the lungs. That allows for air

40:22 come in. And what it does you to exchange air with the external

40:27 to the internal environment. So that cells which use oxygen can then use

40:31 or receive oxygen, and the carbon it produces can then be expelled.

40:36 , it's a specific system to allow that particular chemical tickle to come into

40:41 body in a regulated way. We've the cardiovascular system, which is your

40:45 and your blood vessels. And the basically. Its job is to move

40:48 around the body so that you can the nutrients and the chemicals that the

40:53 need in order to be functional. , it's like a highway delivery

40:57 All right. The immune system and lymphatic are very closely affiliated with the

41:04 system. That's why you can see these things kind of uh that's really

41:07 lymphatic that are doing that. But has a whole bunch of different types

41:10 tissues that are are kind of being . You can see it right

41:14 That would be the spleen. and then up here there would be

41:18 thymus and so on. But these systems that play a role in immune

41:23 . All right. Anything that doesn't to your body is trying to kill

41:27 . Well, it really isn't trying kill you, but it can kill

41:30 . Okay, Right. That's that's many of you guys are wearing masks

41:34 now is because you've been trained to and rightly so that the world is

41:38 to get you. And in particular now, it's a virus that's trying

41:42 get you now. It's not trying kill you, it's just trying to

41:44 itself. But when it takes over , some viruses can be incredibly

41:50 Right? And so your body has mechanism to deal with those things that

41:55 be in your body. That's what immune system is responsible for. All

41:59 . So it plays a role against , viruses, for example are

42:04 So our bacteria, so are all of horrible things that are out

42:09 And the other thing that does it uses this system to filter things through

42:15 basically create a point of contact between blood where most pathogens find their way

42:21 your body and then before they actually their way around your body. Now

42:26 , the immune system will you'll talk more in A&P. two. We

42:29 the endocrine system which isn't really a . It's we have all these things

42:33 do similar things and we're just gonna them in the box together. You

42:38 done that? Like having toys like your dolls And you just say I'm

42:42 to throw all the dolls in the box. Looking at James. He's

42:46 , don't look at me, You know what I'm talking about.

42:50 like, okay, oh, that's perfect example, gold star for the

42:57 . The kitchen drawer, there's that kitchen drawer. The catch all

43:02 I found it. I don't know it goes. It goes in

43:04 All right, I can't find We'll have you checked the kitchen

43:07 That is perfect. Right? That's they did with these systems. All

43:11 now what is the thing they have common? They're all hormone secreting

43:15 So it includes all sorts of thyroid pancreas pituitary. So if we're

43:19 through this up there, that would the hypothalamus and the pituitary. There's

43:22 thyroid down there. Those are your right there. That's your pancreas.

43:27 showing gonads as well. These are structures that produce hormones and collectively refer

43:34 them as the immigrant system. But not talking to each other. They're

43:37 to the systems that they're responsible for . Alright, so, that's the

43:41 thing they share in common now. are they controlling them? Well,

43:44 are responsible for growth, metabolism, and physiological homeostasis. I don't know

43:50 I have a parentheses there, but . Alright, so growth and

43:56 All right, That's what they Right, reproductive success and physiological

44:04 All of these different structures we have urinary system, basically. The urinary

44:11 is getting all the bad things out your body, basically filtering out the

44:15 , keeping what your body wants. rid of the things your body doesn't

44:18 . So, it includes the ureter into the bladder and the

44:22 Got the digestive system. I that's the tube through the body.

44:26 can see there's a whole bunch of structures in here. Their job is

44:29 coordinate digestion. When you put a in your mouth, that doesn't just

44:33 to your stomach and digest their digestion in the mouth continues in the stomach

44:38 in the small intestine. You have that put enzymes there to break things

44:42 and then the small intestine as well a large intestine are absorbing everything that

44:47 body wants and leaving everything that your doesn't want. So all that is

44:53 through these different structures. And then have the reproductive systems. Now,

44:58 are sexually dime or fick. what that means is we have male

45:02 female, which means we have two different systems. Males. The reproductive

45:07 consists of the testes, the epidemic's , vast difference. The penis has

45:12 Coppola Torrey organ and the sex glands are responsible for producing the enzymes and

45:17 materials that allow for those sperm cells you're creating in the testes to be

45:22 to travel outward. All right. so that would be the male reproductive

45:26 . The female reproductive system begins with gonads and ovaries as well as the

45:31 tubes and the uterus, the which is the copulate torrey organ as

45:35 as the mammary glands which aren't being and really don't fall under the category

45:41 the reproductive organ itself, but they're kind of a secondary structure. All

45:46 , The function of these two different are to bring these two organisms together

45:51 that they can bring those unique gametes so they can create a unique organism

45:57 the merging of those two gametes that and that over all. Right.

46:01 we produce the gametes, the hormones regulate the process and ultimately in the

46:06 embryonic development. Alright. So, got these really unique structures and they're

46:11 made up of these unique tissues. four different types of tissues which have

46:15 these unique sells about 240 of Right? Not in the same

46:20 And that's how we get you an . And that's what you get to

46:29 in the class. It's a lot stuff. All right. But it's

46:35 stuff. I think. All Are there any questions so far we're

46:39 see where we are. No Everyone's just just let him talk.

46:44 talk himself out. Now. I talk myself out. Go read any

46:48 about me. He's like, man shut up. So, what I

46:55 do is I want to shift gears I want to address um uh you

47:01 , some basic and common anatomical terminology any field you go into there is

47:07 language used by the people in that to help communicate clearly about what they're

47:13 about. It doesn't matter what field go into. Alright. And I'm

47:17 warn you now, biologists are simple . We're simple. Alright. We

47:23 things for what they do or for they look like. All right.

47:27 so when you look at things in or in anatomy, you got to

47:31 the words may look big and but they're not there to trick

47:35 They're there to guide you because we're like the chemists which like to throw

47:39 numbers and slashes and dashes, Like three comma five prime dash Ortho

47:46 , you know, you know, , we're simple. All right.

47:52 , the first thing we need to is that in order to communicate first

47:57 , anna thomas had to have a position for the body. Right?

48:04 other words, if you are, can imagine. So when they first

48:07 doing anatomy, it was illegal. was back in like the 12 hundreds

48:11 if you are cutting up a body called desecration, right? So basically

48:16 would consider you doing all sorts of witchcraft. So people who are doing

48:20 initial type of study of anatomy, doing it in secret. But they

48:24 writing things down and there are people over the world and at the time

48:28 would be european world, right? you have people in italy or Germany

48:32 France and they would all be communicating each other. So they used a

48:35 language, primarily greek or latin. ? But if I'm sitting there describing

48:41 that I'm cutting into, I need have something that is kind of a

48:45 position. So I want something, I have a cadaver lying on the

48:48 , I want it lying in this , I don't want it, you

48:51 , sitting on its knees. But because if I'm sitting there describing something

48:54 being something above something else. You know which position I'm starting in.

49:00 ? So that's what the first thing is the anatomical position. Right?

49:04 this is what we're looking at the position. It looks like a person

49:08 up but you can manage really cadaver the table. Alright. Alright.

49:14 two Basic regions in the body. this out of the way so I

49:19 circle stuff. All right, really to see these two things. All

49:26 . We have the actual region. right, this is make sure it

49:31 . That is your axial region, head, your neck and your

49:35 Everything that extends from that axis as appendix. Right? Your arms are

49:42 . Your legs are appendices. So is the actual region that I just

49:47 and then I'm just gonna go over because it's easier. These is the

49:53 color regions. So it's your legs your arms. If I cut off

49:58 arms and legs, are you gonna ? Well, you might but you

50:04 but I mean if we did it say they were oh, I don't

50:07 , some sort of alien disease. we had to cut those things off

50:10 to save your life, would you ? No, you'd be basically a

50:17 and head in the neck and you'll just fine. Right? But if

50:20 cut off your trunk are you going live? How about your head?

50:24 know, you're doomed. Alright. that's an easy way to think about

50:27 head and the neck and the and trunk. I need to live.

50:32 appendices. I like them. But could do without. All right.

50:36 the way you can think about All right. There's also regional or

50:43 specific regions within the body. Now a big long list of stuff.

50:46 not gonna ask you these. Do memory memorize this slide, but when

50:50 hear words start putting them into your as in like store them away because

50:55 a way that we can communicate. right. So some of these,

50:58 already know like the bottom of the is planter, right? And you're

51:02 , well I don't know that You sure you do. Have you

51:04 had a wart on the bottom of foot? What did you call

51:07 A Planter's wart. It's not named some guy named planter. It's telling

51:11 where it's actually located. It's the wart, it's underneath the bottom of

51:16 foot. Okay, that's kinda Alright, well let's do some simple

51:20 . If you do manual labor, kind of work are you doing?

51:25 , you're working with your hands. a manual right? There's one that's

51:29 weird. I mean cranial is You know some of these like,

51:32 know your armpit axillary? You've probably that one right? The hair under

51:36 arms. Axillary hair. You armpit . Alright. Alright. Here's the

51:41 one. I just pointed out just it's fun your chin right there.

51:46 called the mental region. I don't why I wanted to look it up

51:51 class. I do it every year I just I put it in and

51:55 dump it and I just didn't. you can go look it up and

51:57 why is that name until Yeah, could very well be well.

52:03 so, so this region right That's that's good. I mean,

52:06 fact, that type of thinking is akin to how a biologist thinks.

52:10 this region right here, what's that on your head? That's your

52:14 Right. Temple refers to time. would they call this the time

52:19 Because as you age, the first that gets gray is there. So

52:24 shows the passage of time. So could very well be like some

52:30 Mm hmm. But they do. where something. So anyway, you

52:35 , I mean, some of these , like I said, you

52:37 gluteal and so on and so So just recognize that there are specific

52:41 to direct you to specific areas on body. All right. And as

52:45 anonymous we're going to be using those . You do not need to memorize

52:50 list. All right. Now. body has holes in it. What

52:56 call cavities, cavities are not the you have in your mouth when you

53:01 too much sugar. There's actually a . I know I have a pre

53:05 in here. Someplace. What are called? Say it. Say it

53:10 carries. It's the weirdest thing ever . You're you're right. That's how

53:15 refer to it. And it's like first time I ever heard that was

53:17 what? Now? That's cavity. , no. It has other

53:21 right? But for the layperson it's hole in the tooth. So it's

53:24 cavity. Alright. So in the a cavity is simply a hollow area

53:29 , winning with the hollow area within . All right. So, most

53:34 are true cavity in the body should fluid in it. So, it

53:38 be a fluid filled space very When we look at these cavities,

53:41 not going to see the fluid. right. Um For us there are

53:45 primary cavities. What is called the cavity. That's the one on the

53:50 and then we have the ventral That's the one in the front.

53:52 right. And we'll get to the area nomenclature here in just a

53:57 Alright, so, to distinguish between two things I I I've got these

54:02 for you first. The dorsal cavity completely encased by bone. Alright.

54:07 actually the first one to develop. is developmentally separated from the ventral

54:13 So there's blue, right here is from those it does when you develop

54:18 blue cavity develops first and then in separate event. Those other cavities.

54:23 red and the green one developed Alright, so they never developed at

54:28 same time. Now, this is continuous structure. Alright. We refer

54:32 this region up here as the cranial . The cranial cavity is where the

54:36 is found. And then the extension the spinal cord from the brain continues

54:42 through the dorsal cavity. In the where the spinal cord is found is

54:45 to as the spinal cavity. I told you biologists are simple people.

54:50 name things for what they do or what they look like. So,

54:52 can already see here is an example the things that we're naming right.

54:58 because the bone structure up here is the cranium. So, the cavity

55:03 the cranium is the cranial cavity. right. This is where the spinal

55:08 is housed. Hence spinal cavity. , the ventral cavity is unique.

55:13 much much larger. Alright. It's front of it. So, that's

55:18 rent ventral right? It has within a bunch of serious or serious membranes

55:23 we're going to get to when we about the epithelium. All right.

55:27 it has two subdivision is divided by muscle called the diaphragm. So,

55:32 what you have here is in the cavity. You can think I have

55:34 diaphragm here. The region on the the diaphragm superior to the diaphragm is

55:40 the thoracic cavity. The region below diaphragm is the abdominal pelvic cavity.

55:46 right. So, with regard to thoracic cavity, there it is.

55:52 , so, here you can see thoracic cavity. It has different compartments

55:56 it. Again. We're using compartments create environments that are unique from the

56:01 areas to do unique things. So every time you divide something,

56:05 have to ask the question, why that divide it? Because there's something

56:09 going on inside there. Alright, , the compartments include the pleural

56:13 That's the two things in red the pleural cavities are where you How's

56:19 lungs? All right now, the we said we said that all the

56:24 in the abdominal pelvic have these serious . So, the serious membranes surrounding

56:28 lungs has a special name. It's the pleura pleural cavity basically surrounds the

56:34 . And you can think of this a double structured membrane. I want

56:40 see if I can do this for where anyone can see it later.

56:43 your way in the back, all have is blue. Alright, what

56:47 say is if we have a structure the lung, it's basically a structure

56:52 is adhered to the outer surface of lung and then there's a second membrane

56:57 surrounds it. Like So, and that that's where you're gonna see the

57:01 . That's a serious fluid the purpose these structures is to ensure that we

57:07 something that is moving. That doesn't friction. All right now, whenever

57:13 have a serious membrane, you have two layers. The two layers have

57:17 names? The one that's touching the is called the visceral layer. The

57:23 that's touching the away from the usually touching the the outer wall of

57:28 cavity is called the parietal layer. it's easy to remember if you can

57:32 of all my guts, all my are referred to as the viscera.

57:39 , whenever you're going, okay, can't remember which one's which.

57:41 yeah. Well, this side is the guts, your lungs being

57:46 It's not you think of guts as down here? But all the organs

57:50 your body, right? The stuff don't eat. Do you eat your

57:57 ? Mm hmm. Anyway, the , whatever it's touching next viscera.

58:04 , so it's filled with this serious surrounds the lung. And that purpose

58:07 that serious fluid is so that when organ is moving, it doesn't create

58:12 . Because when you create friction, you create heat? Alright, I'm

58:19 tell you something you don't want to about yourself. You're made of

58:23 Did you know that you are your ? How do you know this?

58:28 I put you in a tiger cage the tiger? Go down?

58:30 I'm not gonna touch that. That's plant. What's the target going to

58:34 ? He's going to eat the You're the meat. All right.

58:38 if I take heat and meat? do I get steak? Right?

58:45 become cooked meat, Right? you can imagine friction creates heat if

58:51 have a lung and I'm putting heat it. I'm cooking it and then

58:55 doesn't move anymore and then it becomes functional. So you need serious membranes

59:01 prevent that from happening. You don't see it here around the lungs.

59:06 we said there's three cavities or three of the first one of the pleural

59:13 . There we go. So, guess I wasn't the right one.

59:17 , I was sorry, the same . I was very confused.

59:20 The second compartment is this region, the yellow and the purple together.

59:25 called the media steinem. Alright. basically sits behind the sternum. It's

59:31 entire cavity in the middle. All . The media steinem houses the

59:37 It houses the thymus. It houses trachea. And the esophagus. The

59:41 is how you get air um down your lungs. The esophagus is how

59:46 get food down to your belly. right. So it houses a whole

59:51 of structures, but you also have important structure that we just mentioned.

59:56 heart. The heart is in its compartment inside the media steinem.

60:03 And that's called the pericardial cavity. right. Perry means next to.

60:07 basically it's the cavity inside that surrounds is right next to the heart.

60:13 has a serious membrane which we call pericardium. Alright, the outer

60:20 Once again, the one that's away the heart is the parietal, the

60:23 that's up against the heart is the layer. And again fill the series

60:29 . Series fluid prevents friction. Why we need to prevent fiction? Because

60:35 made of meat and we don't want cook the heart? Is your heart

60:39 moving? Yeah. So, you imagine kind of important. I don't

60:43 my heart to stop moving and the is made up of cardiac muscle.

60:49 really when we think of meat, thinking of muscle and so your heart

60:53 basically a big giant steak waiting to cooked. All right, moving down

61:01 little bit further, we have the cavity and the pelvic cavity. This

61:05 the abdominal pelvic region. All So how do we separate out these

61:11 ? Well, find your hips. know where your hips are,

61:14 They sit right there. So that edge of your iliac crest is the

61:19 line between the abdomen and the Alright, so the abdominal cavity is

61:25 where you're gonna find the digestive A whole bunch of structures as well

61:28 the kidney and the your orders. right, basically, it's partially protected

61:34 the lower ribs. All right. you can sit right here and go

61:37 a second. Okay. He said up here. But if you feel

61:40 can go wow my ribs come down this and it's protecting part of my

61:46 region. And again, so when find ribs protecting something that's probably something

61:51 you need in order to live, ? So we're doing is we're protecting

61:55 liver for the most part, We're protecting our kidneys for the most

62:00 in the back. Alright, those things pretty important. And then you

62:05 see down here this is the pelvic , that's the inferior cavity. These

62:09 really important. And you know that organs are really important because the bones

62:15 . And what do we find in pelvic region? All the reproductive

62:20 Well, in males, the strategy mammals is to move the testes out

62:27 from the body. So those aren't so protected. But ladies, you

62:31 important stuff because it's protected, That's what the hip girdle or the

62:36 girdle is responsible for. Now the is down there as well. It's

62:40 , you know, a design right? But basically the reproductive organs

62:46 in the pelvic cavity. Okay, anatomists got to watch my time

62:59 It's confusing on my thing. I a clock. That is the actual

63:03 . And then one that's a timer it tells me how much time has

63:07 by. And so when I sometimes at the timer thing, I

63:12 It's like, Oh no, it's . That's I panic. So alright

63:17 , so anonymous. Like I we're going to use specific language to

63:23 things easy to understand where we're located what we're looking at. So they'll

63:27 like descriptive or some sort of They'll have that regional terminology that they'll

63:32 that to point you to where you to be looking. All right.

63:35 so this is where that regional anatomy the regional language needs. You need

63:40 start as you go along. And for example a descriptive might be something

63:45 left or right. And really what doing is when you're saying left or

63:48 , you're looking at something and you're that's left. Not my left,

63:52 ? So if you're looking at me is my my right, right.

63:56 that's your left. Alright. So always have to remember it's the subject

64:01 I'm looking at or the patient that looking at. That's what I'm referring

64:05 , not mine, right? Because look at this, you know that's

64:08 left. No no that's my that's right. See All right.

64:14 So that's the descriptive so you can the right, left, right,

64:17 , right, left. Alright. use prefixes, prefixes are also kinds

64:20 descriptive. And so they're they're more an ancient descriptive. So if you

64:24 like hypo or epi hypo refers to epi means above. Alright. So

64:30 you see like for example here hipaa or epic gastric it's telling you above

64:35 below and then they're using that regional to tell you where you're looking and

64:39 moving from that particular position and that's all these regions are. So the

64:44 region gastric refers to the belly. basically saying above the belly region or

64:49 the lower belly region, contract, example, means cartilage. So it

64:54 , hey, go to where you the cartilage on the bone, there's

64:58 on these bones. That's where you're in this particular case lumbar refers to

65:03 region, The lumbar, it's a of the back. So it's like

65:07 there iliac, for example, refers where the hip is located. So

65:11 can see anatomists are trying to direct to where you need to be looking

65:16 the terminology that they have here. so you can see for the abdominal

65:20 region, we have nine regions. what anatomists do. Now, you

65:24 are going to be an artist, one of you might be an

65:27 It'd be really cool if that but highly unlikely, really. So

65:32 of you guys are planning on So, in medicine, um,

65:35 don't have time to kind of go all that kind of specifics. So

65:39 more like, okay, we're just divide it into four and so its

65:43 and lower and left and right. know. So these are the four

65:46 that they would use for the the of the belly. So it's

65:52 it's quicker, it directs you to general area that you need to

65:55 And so it's not quite as So, I kind of understand that

66:00 we're doing here is more academic and of what you may see when you

66:04 on into your professional career. Yeah. So don't don't correct the

66:11 when they say this is the upper quadrant said no, no,

66:14 no. I learned that was the really. All right. These terms

66:19 do need to know. All These are are fairly basic terms that

66:23 you to understand the relationship between All right. And so, these

66:30 descriptive terms, You'll hear me use over and over again. Alright,

66:33 , I'm not gonna try. I end up going through every one of

66:36 . I don't want to, but do. So, proximal versus distal

66:39 probably the most complex. Proximal means distal means far away. Alright,

66:45 , it's a relative term, So my foot is more distal than

66:50 knee. My knee is more proximal my foot to the core of my

66:55 . So, typically when you hear terms proximal distal, it's referring to

66:59 the core is alright. But you have to see in context. They

67:05 change the context on you. So and see if context is being applied

67:10 . So, for example, my is proximal to my fingers more so

67:15 my elbow, which is which is distal but notice where the context was

67:23 I'm pointing relative to my fingers, ? But 99% of the time context

67:30 the core of the body. So can just think this is proximal,

67:34 distal. That's further away. The of these are pretty straightforward, ventral

67:39 dorsal. If you can get these confused, just think of a fish

67:43 a shark. What's that thing on back of a shark called dorsal

67:47 Alright. You know that you're good go? Alright, dorsal versus

67:52 Sometimes those are more commonly used terms , but previously it was anterior versus

67:58 when you were a bad child. mom or your dad gave you a

68:02 power on your boom, boom, , And that was your posterior.

68:08 that's the way to remember. lateral versus medial is again, it's

68:12 relationship. The midline of your body what we call your meat. It

68:16 be medial. So towards the midline you move away from the midline,

68:21 lateral. Alright. We have superior inferior that is specific to humans.

68:28 . We don't refer when we're talking animals because I do know we have

68:32 vet. Yeah, there we We don't use that in in other

68:38 . We use cranial versus coddle. refers towards the butt cranial refers towards

68:45 head. Alright, But humans stand , so this is superior. That's

68:51 . Um I think that's everything on . But you can see everything has

68:56 this versus that. Now, your , you're three dimensional structure. Would

69:03 agree? Yeah. If I took mirror and and lined it up at

69:08 midline alright, you would see that reflection would be a mirror image would

69:14 as if you're a perfect organism, ? And so you can see that

69:18 is a line that can go through body, but I can also cut

69:22 into other different directions, right? can saw you in half like a

69:26 trick, right? And I can you this way as well,

69:31 We're front versus back. So you think of, I gotta front versus

69:35 . I gotta top versus bottom. I got a left versus right.

69:38 those are your three planes and they names. Sometimes it's really easy to

69:42 confused. So, I'm gonna try help you with one. The first

69:44 is Corona. All right. You know the statue of Liberty. The

69:49 of Liberty wears a crown. That is not like the Queen of

69:54 which is around about the head. sits like this on the top of

69:57 head. And what it does is separates the front versus the back.

70:03 the crown separates front versus back. , Front versus back. All

70:07 now notice these are going like right the middle of your body. But

70:12 could be, I could cut the of your nose off in a colonial

70:15 and just look at what's going on there, that would be a coronal

70:18 . If I'm cutting front versus that's corona. Alright. If I'm

70:23 left versus right, that's sagittal. . If I'm cutting directly in the

70:29 , that's mid sagittal. Which is you have up there. So recognize

70:35 and the common one is mid Alright, But saddles left versus

70:39 All right. And then top versus is transverse. Alright, I'm cutting

70:45 in half and I'm looking to see there from this direction. Alright,

70:49 top versus bottom. So you should able to do that and again notice

70:54 the pictures. Are we in the position. Yeah. And I want

70:59 point out anatomical position. Hands, face outward. All right. It's

71:04 like this, that's like that. right. I think hold on a

71:12 . I'm gonna skip over this real because that was from the previous

71:15 Alright, so the last little bit and I have what? Like Five

71:23 , 10 minutes. Really? Less 10 minutes. I want to just

71:26 this concept of homeostasis to you and that should be the last thing and

71:30 we'll go then we'll go home. . I think I saw one head

71:35 asleep over on that side. All right. So homeostasis simply is

71:41 body's ability to maintain relatively stable internal despite constant change in the external

71:48 throw the picture of the two, dumped, jumping themselves in the snow

71:52 the inside of their body right now 98.6 degrees despite the fact that it's

71:57 enough to have snow and look at happy they are. See the happy

72:01 , they're smiling, right? So would be an example of homeostasis.

72:05 we say is that it's a dynamic of equilibrium or balance. So dynamic

72:12 has implication to it. What does mean movement? But it also has

72:18 state steady state, right? And two movement and steady are words that

72:24 necessarily go together, do they? what this implies is that I'm trying

72:28 keep something constant by moving things in to something else that's moving.

72:34 think of yourself trying to balance on center of a seesaw right? You're

72:41 your upper body stable while your legs doing this, while the seesaw is

72:46 back and forth, the external things , but your upper body is what

72:50 keeping steady. Right? That would an example. So what we say

72:54 when you see that word homeostasis, saying the needs of the body are

72:58 adequately met and it is functionally smoothie . Alright, pathology is when homeostasis

73:07 not working alright, this diseases in body is when homeostasis is missing.

73:13 , so pathology is contrary to Homeostasis is physiology what you should be

73:21 all right now, how does it about doing this? Alright, We

73:25 temperature a lot because temperature is easy to concede. But really homeostasis isn't

73:30 temperature. There's all sorts of different that your body is monitoring at any

73:34 time. We refer to this as variable. Alright. That variable.

73:38 the process is is can is supposed be able to change. So,

73:43 right now, I'm just gonna use example, the room is bright.

73:47 ? So your body is monitoring the of brightness so to determine how much

73:54 it needs to allow into your eyes that you can see clearly.

73:58 If I turned off the lights, room would become dark. There would

74:02 a change in how much light there . That would be a stimulus and

74:06 body now has to respond to allow to see that makes sense.

74:13 So, stimulus is a change in variable. The variable is just something

74:17 we're monitoring. All right now, that means is you have to have

74:21 that does the monitoring that's called a . Alright. What we've referred to

74:25 the sensor. All right. We to have something that interprets what that

74:29 means. That would be the That's typically the nervous system. Not

74:33 , but typically it is all And then we have some sort of

74:37 . Er That's the thing that changes response to the stimulus. So,

74:42 the stimulus changes detected tells the control the controller tells the defector, something

74:47 happened. You need to do this that's when the responses. So,

74:50 I turned out the lights, the would get dim. Your eyes would

74:54 the darkness or the less light it . The signal would go up to

74:59 brain and say you need to dilate pupils to allow more light into the

75:04 so that we can see as well we were previously. That would be

75:09 example. All right. So, a normal range When you're talking about

75:14 . So, you've been trained your life. I'm gonna deal with temperature

75:18 . What is the normal set point temperature in a 98.6? The truth

75:25 that's actually not correct. But we're to go with it. Okay.

75:28 actually been starting to look at It's like the actual thing is a

75:32 bit lower. And they think that have been naturally infected for the entire

75:37 of mankind. And so, we a natural fever that kind of raises

75:40 temperature up to 98.6. It looks our natural temperature is closer to 97.7

75:46 something like that. All right. very small. But if you notice

75:50 you ever go and get the because face it, how many of you

75:53 have had your temperature taken like 1000 this last year. Right? And

75:56 you notice like my temperature is a lower. It's not 98.6. That

76:00 be special and unique. No, , that's normal. Okay.

76:08 Well, I'm gonna, you you don't even know the specific.

76:11 think of it as an example. this is another way another way to

76:16 at it. Right? Same, slide, different picture. It shows

76:20 look there's variability. So think of 98.6, you know, your body

76:25 is going to change throughout the course the day, depending upon whatever it

76:28 . When you wake up, your temperature is actually a little bit

76:31 When you go to bed, your temperature a little bit higher, but

76:33 lower. So there's a range in your body temperature is okay.

76:37 So if it's not where you're going use 98.6. If you're 98.4,

76:41 body is not panicking, right? like, oh no, it's the

76:43 of days right now. But if , if something happens, like your

76:49 begins heating up right there are internal and go, wait a second.

76:54 isn't right. It's too hot. is bad for the body. So

76:59 need to burn off heat. How I burn off heat? I

77:04 Right, so bestow dilate, put little bit of water on the

77:07 let that heat go to the water gets whipped off and off it

77:11 . You just watched a sensor, nervous system saying it's too hot.

77:16 need to sweat, hey, sweat start sweating. That's your factor.

77:21 effect is what causes the effect. right. So what we're looking for

77:25 trying to keep us in that Right? And we can change the

77:29 point when you get sick. What you get? A fever? A

77:35 is a natural change in the set because the body is detected something is

77:40 right in the body. We must an infection. What can we do

77:44 the infection? Let's kill off the that's infecting us. I'll raise the

77:48 temperature to a new set point which can function at kind of But definitely

77:53 organism that has infected shouldn't be able function at that. That's really what

77:57 fever is basically me trying to kill something that's infected. Mhm. And

78:02 think that was the last slide. these two things go hand in

78:05 So we have to do it. how do we do this primarily?

78:08 use two different mechanisms. One is feedback. One is positive feedback.

78:13 feedback is when you take that that stimulus and you're saying, oh it's

78:19 out of range. So I'm going respond in a way to bring it

78:24 down into range. Alright, that's feedback. The example I have here

78:29 just the thermostat. It gets too . What do I do is it's

78:33 of range. So now I'm going bring my temperature back down into range

78:38 something in the opposing manner. Last , positive feedback, positive feedback is

78:46 rare in the body. It's it's a type of home and static

78:50 . But what we're doing is removing set point further and further and further

78:55 from the original set point and by so, what we're gonna do is

78:58 monitoring the change and we're driving the further and further away. All

79:04 So, the idea you can think this, if I take a pebble

79:07 put it on top of a hill there's snow and drop it. It's

79:10 create a snowball. The snowball gets and bigger and bigger and bigger and

79:14 . Right? Because I'm adding more more snow. So in the

79:18 an example of the two primary examples we use is contractions during labor,

79:25 ? Baby presses on the cervix, a signal goes up to the brain

79:28 says create more pushing to push against cervix. So basically, it's a

79:33 to create stronger and stronger and stronger . That would be a positive

79:37 All right. The other one is baby latches to the breast begins

79:43 That's the feedback mechanism to say start let down as long as that baby

79:47 suckling I'm gonna keep producing when the falls asleep, stop suckling. I

79:52 producing. So the positive feedback is produce the milk. So this is

79:56 less common mechanism. But these are to do homeostasis. They are not

80:03 themselves. They are mechanisms to work that set point. All right,

80:11 , long first day, wasn't Alright, when we come back on

80:16 , after we get that nice rest five days, we're going to keep

80:20 and keep running around. There's always now. It's um So we still

80:29 a little bit to do, like three or four slides and then we

80:32 into the next one. Just follow whatever the reading tells you to

80:40 .

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